Murphy P M, Mayers D L, Brock N F, Wagner K F
Bacterial Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Rev Infect Dis. 1989 Mar-Apr;11(2):335-7. doi: 10.1093/clinids/11.2.335.
Postvaccination subcutaneous abscess due to bacille Calmette-Guérin (BCG) is an uncommon complication and is especially rare in the United States, where the general population is not vaccinated with BCG. This type of abscess is usually chronic, and optimal therapy has not been defined. Two Americans, a husband and wife, underwent primary BCG vaccination abroad and developed chronic subcutaneous abscesses at the primary inoculation site. Four months after vaccination, Mycobacterium bovis strain BCG was cultured from material aspirated from both lesions. Direct susceptibility studies revealed a minimal inhibitory concentration of less than 3.0 micrograms of erythromycin/mL for both isolates. Erythromycin was given orally to the husband and wife for 3 and 4 weeks, respectively, during which time complete healing occurred in both cases.
卡介苗（BCG）接种后引起的皮下脓肿是一种罕见的并发症，在美国尤为罕见，因为普通人群未接种卡介苗。这种类型的脓肿通常是慢性的，尚未确定最佳治疗方法。两名美国人，一对夫妻，在国外接受了卡介苗初种，并在初次接种部位出现了慢性皮下脓肿。接种疫苗四个月后，从两个病变部位抽取的材料中培养出牛分枝杆菌卡介苗菌株。直接药敏试验显示，两种分离株对红霉素的最低抑菌浓度均低于3.0微克/毫升。分别给这对夫妻口服红霉素3周和4周，在此期间，两人的脓肿均完全愈合。
