Lau Jeffrey M C, Laforest R, Sotoudeh H, Nie X, Sharma S, McConathy J, Novak E, Priatna A, Gropler R J, Woodard P K
Division of Cardiovascular Disease, Department of Internal Medicine, Washington University in Saint Louis, Campus Box 8086, 660 S. Euclid Avenue, Saint Louis, MO, 63110, USA.
Department of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University in Saint Louis, Saint Louis, MO, USA.
J Nucl Cardiol. 2017 Jun;24(3):839-846. doi: 10.1007/s12350-015-0197-1. Epub 2015 Oct 23.
Simultaneous acquisition Positron emission tomography/magnetic resonance (PET/MR) is a new technology that has potential as a tool both in research and clinical diagnosis. However, cardiac PET acquisition has not yet been validated using MR imaging for attenuation correction (AC). The goal of this study is to evaluate the feasibility of PET imaging using a standard 2-point Dixon volume interpolated breathhold examination (VIBE) MR sequence for AC.
Evaluation was performed in both phantom and patient data. A chest phantom containing heart, lungs, and a lesion insert was scanned by both PET/MR and PET/CT. In addition, 30 patients underwent whole-body F-fluorodeoxyglucose PET/CT followed by simultaneous cardiac PET/MR. Phantom study showed 3% reduction of activity values in the myocardium due to the non-inclusion of the phased array coil in the AC. In patient scans, average standardized uptake values (SUVs) obtained by PET/CT and PET/MR showed no significant difference (n = 30, 4.6 ± 3.5 vs 4.7 ± 2.8, P = 0.47). There was excellent per patient correlation between the values acquired by PET/CT and PET/MR (R = 0.97).
Myocardial SUVs PET imaging using MR for AC shows excellent correlation with myocardial SUVs obtained by standard PET/CT imaging. The 2-point Dixon VIBE MR technique can be used for AC in simultaneous PET/MR data acquisition.
同时采集正电子发射断层扫描/磁共振成像（PET/MR）是一项新技术，在研究和临床诊断中都具有作为工具的潜力。然而，心脏PET采集尚未通过磁共振成像进行衰减校正（AC）的验证。本研究的目的是评估使用标准的两点 Dixon 容积内插屏气检查（VIBE）磁共振序列进行AC的PET成像的可行性。
在体模和患者数据中均进行了评估。对一个包含心脏、肺和病变插入物的胸部体模进行了PET/MR和PET/CT扫描。此外，30例患者先进行了全身F-氟脱氧葡萄糖PET/CT检查，随后进行了心脏PET/MR同步检查。体模研究显示，由于在AC中未包含相控阵线圈，心肌的活性值降低了3%。在患者扫描中，PET/CT和PET/MR获得的平均标准化摄取值（SUV）无显著差异（n = 30，4.6±3.5 vs 4.7±2.8，P = 0.47）。PET/CT和PET/MR获得的值之间在每位患者中具有极好的相关性（R = 0.97）。
使用磁共振进行AC的心肌SUVs PET成像与标准PET/CT成像获得的心肌SUVs具有极好的相关性。两点 Dixon VIBE磁共振技术可用于同时进行的PET/MR数据采集中的AC。
