血清铁蛋白水平与代谢综合征及胰岛素抵抗的关联
Association of Serum Ferritin Levels with Metabolic Syndrome and Insulin Resistance.
作者信息
Padwal Meghana K, Murshid Mohsin, Nirmale Prachee, Melinkeri R R
机构信息
Professor, Department of Biochemistry, Bharati Vidyapeeth University Medical College , Pune, India .
Student, Bharati Vidyapeeth University Medical College , Pune, India .
出版信息
J Clin Diagn Res. 2015 Sep;9(9):BC11-3. doi: 10.7860/JCDR/2015/13480.6564. Epub 2015 Sep 1.
INTRODUCTION
The impact of CVDs and Type II DM is increasing over the last decade. It has been estimated that by 2025 their incidence will double. Ferritin is one of the key proteins regulating iron homeostasis and is a widely available clinical biomarker of iron status. Some studies suggest that prevalence of atherosclerosis and insulin resistance increases significantly with increasing serum ferritin. Metabolic syndrome is known to be associated with increased risk of atherosclerosis as well as insulin resistance.
AIM
The present study was designed to explore the association of serum ferritin levels with metabolic syndrome and insulin resistance.
MATERIALS AND METHODS
The present study was prospective, cross sectional. The study protocol was approved by IEC. The study group consisted of 90 participants (50 cases of metabolic syndrome and 40 age and sex matched controls). Diagnosis of metabolic syndrome was done as per NCEP ATP III criteria. Estimation of serum Ferritin and Insulin was done by Chemiluminescence Immunoassay (CLIA) while Glucose by Glucose Oxidase and Peroxidase (GOD-POD) method. Insulin Resistance was calculated by HOMA IR score.
STATISTICAL ANALYSIS
Data obtained was statistically analysed by using student t-test.
RESULTS
We found statistically significant rise in the levels of serum ferritin (p=<0.001), glucose (p=<0.001), insulin (p=<0.001) and HOMA IR score (p=<0.0001) in cases of metabolic syndrome as compared with controls.
CONCLUSION
High serum ferritin levels though within normal range are significantly associated with both metabolic syndrome and insulin resistance.
引言
在过去十年中，心血管疾病（CVDs）和2型糖尿病（DM）的影响日益增加。据估计，到2025年它们的发病率将翻倍。铁蛋白是调节铁稳态的关键蛋白质之一，是一种广泛可用的铁状态临床生物标志物。一些研究表明，随着血清铁蛋白升高，动脉粥样硬化和胰岛素抵抗的患病率显著增加。已知代谢综合征与动脉粥样硬化风险增加以及胰岛素抵抗有关。
目的
本研究旨在探讨血清铁蛋白水平与代谢综合征和胰岛素抵抗之间的关联。
材料与方法
本研究为前瞻性横断面研究。研究方案经独立伦理委员会（IEC）批准。研究组由90名参与者组成（50例代谢综合征患者和40例年龄及性别匹配的对照）。代谢综合征的诊断按照美国国家胆固醇教育计划成人治疗组第三次报告（NCEP ATP III）标准进行。血清铁蛋白和胰岛素通过化学发光免疫分析（CLIA）进行测定，而血糖通过葡萄糖氧化酶和过氧化物酶（GOD-POD）法进行测定。胰岛素抵抗通过稳态模型评估胰岛素抵抗（HOMA IR）评分计算。
统计分析
所获得的数据采用学生t检验进行统计学分析。
结果
我们发现，与对照组相比，代谢综合征患者的血清铁蛋白水平（p<0.001）、血糖水平（p<0.001）、胰岛素水平（p<0.001）和HOMA IR评分（p<0.0001）有统计学意义的升高。
结论
高血清铁蛋白水平虽在正常范围内，但与代谢综合征和胰岛素抵抗均显著相关。
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