Grundy Scott M
Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y3.206, Dallas, Texas 75390-9052, USA.
J Clin Endocrinol Metab. 2007 Feb;92(2):399-404. doi: 10.1210/jc.2006-0513.
The metabolic syndrome (MetS) is a multiplex risk factor for cardiovascular disease. The syndrome develops through interplay of obesity and metabolic susceptibility.
This article addresses whether the MetS construct has clinical utility. POSITION: The National Cholesterol Education Program and other organizations have proposed that the MetS can be recognized clinically by a clustering of simple clinical measures including waist circumferences, blood pressure, triglycerides, high-density lipoproteins, and glucose. People with this clustering have most or all of the components of the MetS. Identifying the MetS has several advantages. It discovers persons who are at increased risk for cardiovascular disease. A diagnosis focuses more clinical attention on the underlying causes, notably obesity and other lifestyle factors; it thereby reinforces the utility of lifestyle changes in clinical practice. A diagnosis further informs physicians on choice and intensity of drug therapy for elevated cholesterol, aspirin prophylaxis, and blood pressure and glucose control. The introduction of the MetS has led to a large number of epidemiological, metabolic, and genetic studies that have heightened our understanding of the condition's prevalence and pathogenesis. It has been a stimulus to the development of new drugs or drug combinations that will modify multiple risk factors simultaneously.
This author holds that the MetS counts as a multiplex cardiovascular risk factor that is clinically useful and will lead to advances in diagnosis and treatment of an important cause of cardiovascular disease.
代谢综合征（MetS）是心血管疾病的多重危险因素。该综合征通过肥胖与代谢易感性的相互作用而发展。
本文探讨代谢综合征这一概念是否具有临床实用性。
国家胆固醇教育计划及其他组织提出，代谢综合征可通过包括腰围、血压、甘油三酯、高密度脂蛋白和血糖在内的一系列简单临床指标的聚集在临床上得到识别。具有这种指标聚集的人具有代谢综合征的大部分或所有组成部分。识别代谢综合征有几个优点。它能发现心血管疾病风险增加的人群。诊断能将更多临床注意力集中在潜在病因上，尤其是肥胖和其他生活方式因素；从而强化了生活方式改变在临床实践中的作用。诊断还能进一步指导医生在选择和确定针对胆固醇升高、阿司匹林预防、血压和血糖控制的药物治疗的选择和强度。代谢综合征概念的引入引发了大量的流行病学、代谢和遗传学研究，加深了我们对该疾病患病率和发病机制的理解。它刺激了能同时改变多种危险因素的新药或药物组合的研发。
本文作者认为，代谢综合征是一种具有临床实用性的多重心血管危险因素，将推动心血管疾病这一重要病因的诊断和治疗取得进展。
