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一项评估因难产行初次剖宫产与维生素D缺乏之间关联的病例对照研究。

A Case Control Study to Evaluate the Association between Primary Cesarean Section for Dystocia and Vitamin D Deficiency.

作者信息

Sebastian Ajit, Vijayaselvi Reeta, Nandeibam Yohen, Natarajan Madhupriya, Paul Thomas Vizhalil, Antonisamy B, Mathews Jiji Elizabeth

机构信息

Registrar, Department of Obstetrics and Gynaecology, Christian Medical College , Vellore, Tamilnadu, India .

Associate Professor, Department of Obstetrics and Gynaecology, Christian Medical College , Vellore, Tamilnadu, India .

出版信息

J Clin Diagn Res. 2015 Sep;9(9):QC05-8. doi: 10.7860/JCDR/2015/14029.6502. Epub 2015 Sep 1.

Abstract

BACKGROUND

Milder forms of vitamin D deficiency could be responsible for poor muscular performance causing dysfunctional labor. The aim of our research was to study the association between vitamin D deficiency and primary cesarean section.

MATERIALS AND METHODS

This was a case control study. Forty six women who delivered by primary cesarean section with dystocia as primary or secondary indication after 37 weeks of gestation were taken as cases and a similar number of women who delivered vaginally were taken as controls. Vitamin D deficiency was diagnosed when the serum 25(OH)D level was ≤20 ng/ml and this was compared between cases and controls.

RESULTS

Median serum (OH) vitamin D levels was 23.3ng/ml among women who delivered by cesarean section and 26.2ng/ml among controls (p=0.196). Baseline characteristics were similar in both groups except for a strong association between Body Mass Index (BMI) and cesarean section, (29.7kg/m(2) in cases and 25.9kg/m(2) in controls p=0.001) seen in multivariate analysis. Vitamin D deficiency was seen in 34.8% of cases and 21.7% of controls (p=0.165).

CONCLUSION

This small case control study did not show a significant association between vitamin D deficiency and primary cesarean section.

摘要

背景

轻度维生素D缺乏可能导致肌肉功能不佳,进而引起分娩功能障碍。我们研究的目的是探讨维生素D缺乏与初次剖宫产之间的关联。

材料与方法

这是一项病例对照研究。将46例妊娠37周后因难产作为主要或次要指征行初次剖宫产的妇女作为病例组,选取相同数量经阴道分娩的妇女作为对照组。当血清25(OH)D水平≤20 ng/ml时诊断为维生素D缺乏,并对病例组和对照组进行比较。

结果

剖宫产妇女血清(OH)维生素D水平中位数为23.3ng/ml,对照组为26.2ng/ml(p=0.196)。除多因素分析显示体重指数(BMI)与剖宫产之间存在强关联外(病例组为29.7kg/m²,对照组为25.9kg/m²,p=0.001),两组的基线特征相似。病例组中34.8%存在维生素D缺乏,对照组中为21.7%(p=0.165)。

结论

这项小型病例对照研究未显示维生素D缺乏与初次剖宫产之间存在显著关联。

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