Gómez-Carrascosa Inmaculada, Sánchez-Ferrer María L, Arense-Gonzalo Julian J, Prieto-Sánchez María T, Alfosea-Marhuenda Emilia, Iniesta Miguel A, Mendiola Jaime, Torres-Cantero Alberto M
Department of Obstetrics & Gynecology, "Virgen de la Arrixaca" University Clinical Hospital, Murcia, Spain.
Institute for Biomedical Research of Murcia, IMIB-Arrixaca, Mucia, Spain.
Nurs Open. 2021 Nov;8(6):3645-3654. doi: 10.1002/nop2.915. Epub 2021 May 15.
The objective of this study was to evaluate associations between maternal concentrations of 25-hydroxyvitamin D (25(OHD)) and birth outcomes: mode of delivery and episiotomy rate.
One hundred and seventeen pregnant women were enrolled in an observational, longitudinal, prospective cohort study. Multivariable linear regression analyses were performed to assess relationships between maternal 25(OHD) concentrations and mode of delivery. To account for systematic temporal variation in 25(OHD), a cosinor model to the data was fitted.
No significant statistical associations were found between adjusted maternal 25(OHD) concentrations and risk of eutocic vaginal delivery, instrumented delivery (OR 1.05 [95% CI: 0.97-1.13]), primary Caesarean section (OR 0.99 [95% CI: 0.88-1.11]) or Caesarean section for any other causes (OR 1.04 [95% CI: 0.95-1.14]). High 25(OHD) levels tended to show a protective effect on performance of episiotomy, without reaching statistical significance (OR 0.36 [95% CI: 0.09, 1.37]).
本研究的目的是评估孕妇血清25-羟基维生素D（25(OH)D）浓度与分娩结局（分娩方式和会阴切开率）之间的关联。
117名孕妇参与了一项观察性、纵向、前瞻性队列研究。采用多变量线性回归分析评估孕妇25(OH)D浓度与分娩方式之间的关系。为解释25(OH)D的系统性时间变化，对数据拟合了余弦模型。
校正后的孕妇25(OH)D浓度与顺产、器械助产（比值比1.05[95%置信区间：0.97 - 1.13]）、初次剖宫产（比值比0.99[95%置信区间：0.88 - 1.11]）或因其他任何原因进行的剖宫产（比值比1.04[95%置信区间：0.95 - 1.14]）风险之间均未发现显著的统计学关联。25(OH)D水平较高往往对会阴切开术有保护作用，但未达到统计学显著性（比值比0.36[95%置信区间：0.09, 1.37]）。
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