Shen Yinghao, Shi Guoming, Huang Cheng, Zhu Xiaodong, Chen Si, Sun Huichuan, Zhou Jian, Fan Jia
Department of Liver Surgery, Zhongshan Hospital, Liver Cancer Institute, Fudan University, 180 Fenglin Road, Shanghai, China.
PLoS One. 2015 Oct 26;10(10):e0140932. doi: 10.1371/journal.pone.0140932. eCollection 2015.
To investigate the role of biomarkers in predicting postoperative liver dysfunction in patients with hepatocellular carcinoma (HCC).
A total of 200 patients operated from July 2009 to June 2010 at Zhongshan Hospital, Fudan University for pathologically confirmed HCC were retrospectively analyzed for clinical data, HBD DNA level and serum biochemical markers for liver fibrosis. The patients were followed up to observersation end point. Correlation of the monitored parameters with postoperative liver dysfunction and patient survival was statistically analyzed.
Preoperative hepatitis B virus (HBV) DNA level, serum prealbumin (PA) hyaluronic acid (HA), and laminin (LN) levels correlated with postoperative liver dysfunction, and preoperative LN level also was associated with the patients' survival. A predictive model was generated using these 4 parameters and validated in 89 HCC patients with sensitivity and specificity of 0.625 and 0.912, respectively [corrected]. However, no correlation was identified between postoperative liver function and overall survival.
Liver fibrosis markers could be preoperatively used in predicting postoperative liver dysfunction in HCC patients.
探讨生物标志物在预测肝细胞癌（HCC）患者术后肝功能障碍中的作用。
回顾性分析2009年7月至2010年6月在复旦大学附属中山医院接受手术治疗且病理确诊为HCC的200例患者的临床资料、乙肝病毒（HBD）DNA水平及肝纤维化血清生化标志物。对患者进行随访直至观察终点。对监测参数与术后肝功能障碍及患者生存情况的相关性进行统计学分析。
术前乙肝病毒（HBV）DNA水平、血清前白蛋白（PA）、透明质酸（HA）和层粘连蛋白（LN）水平与术后肝功能障碍相关，术前LN水平也与患者生存情况有关。利用这4个参数建立了预测模型，并在89例HCC患者中进行验证，校正后敏感性和特异性分别为0.625和0.912。然而，未发现术后肝功能与总生存之间存在相关性。
肝纤维化标志物可在术前用于预测HCC患者术后肝功能障碍。
