与癌症相关的 La 相关蛋白家族

Stavraka Chara, Blagden Sarah

Ovarian Cancer Research Centre, Institute for Reproductive and Developmental Biology, Imperial College, Du Cane Road, London W12 0HS, UK.

Department of Oncology, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LE, UK.

Biomolecules. 2015 Oct 16;5(4):2701-22. doi: 10.3390/biom5042701.

The evolutionarily-conserved La-related protein (LARP) family currently comprises Genuine La, LARP1, LARP1b, LARP4, LARP4b, LARP6 and LARP7. Emerging evidence suggests each LARP has a distinct role in transcription and/or mRNA translation that is attributable to subtle sequence variations within their La modules and specific C-terminal domains. As emerging research uncovers the function of each LARP, it is evident that La, LARP1, LARP6, LARP7 and possibly LARP4a and 4b are dysregulated in cancer. Of these, LARP1 is the first to be demonstrated to drive oncogenesis. Here, we review the role of each LARP and the evidence linking it to malignancy. We discuss a future strategy of targeting members of this protein family as cancer therapy.

进化上保守的La相关蛋白（LARP）家族目前包括真La、LARP1、LARP1b、LARP4、LARP4b、LARP6和LARP7。新出现的证据表明，每个LARP在转录和/或mRNA翻译中都有独特的作用，这归因于它们La模块和特定C端结构域内的细微序列变异。随着新研究揭示每个LARP的功能，很明显La、LARP1、LARP6、LARP7以及可能的LARP4a和4b在癌症中表达失调。其中，LARP1是第一个被证明能驱动肿瘤发生的。在这里，我们综述了每个LARP的作用以及将其与恶性肿瘤联系起来的证据。我们讨论了将该蛋白家族成员作为癌症治疗靶点的未来策略。