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LARP1 功能相关的争议

Controversies around the function of LARP1.

机构信息

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, USA.

Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, USA.

出版信息

RNA Biol. 2021 Feb;18(2):207-217. doi: 10.1080/15476286.2020.1733787. Epub 2020 Apr 1.

DOI:10.1080/15476286.2020.1733787
PMID:32233986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7928164/
Abstract

The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP translation while others that LARP1 activates it. Here, we present opinions from four leading scientists in the field to discuss these and other contradictory findings.

摘要

RNA 结合蛋白 LARP1 近年来因其在 mTOR 信号级联反应中的作用及其对末端寡嘧啶 (TOP) mRNA 翻译的调节而引起关注。矛盾的是，一些科学家表明 LARP1 抑制 TOP 翻译，而另一些则表明 LARP1 激活它。在这里，我们提出了该领域四位领先科学家的观点，以讨论这些和其他矛盾的发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/9d0f580a0958/KRNB_A_1733787_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/cbce46ae02e5/KRNB_A_1733787_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/f65aa568812c/KRNB_A_1733787_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/4c1cb5755d2f/KRNB_A_1733787_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/52601dca6d57/KRNB_A_1733787_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/c894df8b84aa/KRNB_A_1733787_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/ce443bde92b2/KRNB_A_1733787_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/48fb3d4711d1/KRNB_A_1733787_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/9d0f580a0958/KRNB_A_1733787_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/cbce46ae02e5/KRNB_A_1733787_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/f65aa568812c/KRNB_A_1733787_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/4c1cb5755d2f/KRNB_A_1733787_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/52601dca6d57/KRNB_A_1733787_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/c894df8b84aa/KRNB_A_1733787_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/ce443bde92b2/KRNB_A_1733787_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/48fb3d4711d1/KRNB_A_1733787_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb57/7928164/9d0f580a0958/KRNB_A_1733787_F0008_C.jpg

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