Chao Owen Y, Huston Joseph P, Li Jay-Shake, Wang An-Li, de Souza Silva Maria A
Center for Behavioral Neuroscience, University of Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany.
Department of Psychology, National Chung Cheng University, Minhsiung, Chiayi, 62102, Taiwan.
Hippocampus. 2016 May;26(5):633-45. doi: 10.1002/hipo.22547. Epub 2015 Nov 5.
The prefrontal cortex directly projects to the lateral entorhinal cortex (LEC), an important substrate for engaging item-associated information and relaying the information to the hippocampus. Here we ask to what extent the communication between the prefrontal cortex and LEC is critically involved in the processing of episodic-like memory. We applied a disconnection procedure to test whether the interaction between the medial prefrontal cortex (mPFC) and LEC is essential for the expression of recognition memory. It was found that male rats that received unilateral NMDA lesions of the mPFC and LEC in the same hemisphere, exhibited intact episodic-like (what-where-when) and object-recognition memories. When these lesions were placed in the opposite hemispheres (disconnection), episodic-like and associative memories for object identity, location and context were impaired. However, the disconnection did not impair the components of episodic memory, namely memory for novel object (what), object place (where) and temporal order (when), per se. Thus, the present findings suggest that the mPFC and LEC are a critical part of a neural circuit that underlies episodic-like and associative object-recognition memory.
前额叶皮质直接投射到外侧内嗅皮质（LEC），后者是提取与物品相关信息并将该信息传递至海马体的重要基质。在此，我们探究前额叶皮质与LEC之间的交流在多大程度上对情景样记忆的处理至关重要。我们采用了一种切断连接的方法来测试内侧前额叶皮质（mPFC）与LEC之间的相互作用对于识别记忆的表达是否必不可少。结果发现，在同一半球接受mPFC和LEC单侧NMDA损伤的雄性大鼠，表现出完整的情景样（什么-哪里-何时）和物体识别记忆。当这些损伤位于相对的半球（切断连接）时，关于物体身份、位置和背景的情景样和联想记忆受损。然而，切断连接本身并未损害情景记忆的各个组成部分，即对新物体（什么）、物体位置（哪里）和时间顺序（何时）的记忆。因此，目前的研究结果表明，mPFC和LEC是构成情景样和联想物体识别记忆基础的神经回路的关键部分。
