年龄相关性黄斑变性继发3型新生血管的光学相干断层扫描血管造影

OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF TYPE 3 NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION.

作者信息

Kuehlewein Laura, Dansingani Kunal K, de Carlo Talisa E, Bonini Filho Marco A, Iafe Nicholas A, Lenis Tamara L, Freund K Bailey, Waheed Nadia K, Duker Jay S, Sadda SriniVas R, Sarraf David

机构信息

*Doheny Eye Institute, Los Angeles, California; †Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California; ‡Vitreous Retina Macula Consultants of New York, New York, New York; §LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York; ¶Moorfields Eye Hospital, London, United Kingdom; **New England Eye Center and Tufts Medical Center, Tufts University, Boston, Massachusetts; ††Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts; ‡‡CAPES Foundation, Ministry of Education of Brazil, Brasilia, Brazil; §§Stein Eye Institute, Los Angeles, California; ¶¶Department of Ophthalmology, New York University School of Medicine, New York, New York; and ***Greater Los Angeles VA Healthcare Center, Los Angeles, California.

出版信息

Retina. 2015 Nov;35(11):2229-35. doi: 10.1097/IAE.0000000000000835.

DOI:10.1097/IAE.0000000000000835

PMID:26502007

Abstract

PURPOSE

To characterize the vascular structure of Type 3 neovascularization secondary to age-related macular degeneration using optical coherence tomography angiography.

METHODS

Optical coherence tomography angiography cube scans (3 mm × 3 mm) were acquired in 29 eyes of 24 patients with Type 3 lesions secondary to age-related macular degeneration using the RTVue XR Avanti with AngioVue, Split-spectrum amplitude-decorrelation, and motion correction technology. Automated layer segmentation boundaries were adjusted to best visualize the neovascular complex on en face projection images.

RESULTS

A distinct neovascular complex could be identified in 10 (34%) eyes, all of which were active on optical coherence tomography imaging. In all 10 eyes, the neovascular complex appeared as a small tuft of bright, high-flow tiny vessels with curvilinear morphology located in the outer retinal layers with a feeder vessel communicating with the inner retinal circulation (i.e., deep retinal capillary plexus). The mean (SD) size of the neovascular complex measured 0.07 (± 0.07) mm.

CONCLUSION

With optical coherence tomography angiography, it is possible to identify small intraretinal neovascular complexes communicating with the deep retinal capillary plexus in eyes with Type 3 neovascularization secondary to age-related macular degeneration. Qualitative and quantitative analyses of Type 3 neovascular complexes can be performed using optical coherence tomography angiography.

摘要

目的

使用光学相干断层扫描血管造影术来描述年龄相关性黄斑变性继发的3型新生血管形成的血管结构。

方法

使用配备AngioVue、分裂光谱幅度去相关和运动校正技术的RTVue XR Avanti，对24例年龄相关性黄斑变性继发3型病变患者的29只眼进行光学相干断层扫描血管造影立方体扫描（3毫米×3毫米）。调整自动分层分割边界，以在正面投影图像上最佳地显示新生血管复合体。

结果

在10只（34%）眼中可识别出明显的新生血管复合体，所有这些在光学相干断层扫描成像中均为活跃状态。在所有10只眼中，新生血管复合体表现为一小簇明亮、高血流的微小血管，呈曲线形态，位于视网膜外层，有一条供血血管与视网膜内层循环（即深层视网膜毛细血管丛）相通。新生血管复合体的平均（标准差）大小为0.07（±0.07）毫米。