*Department of Ophthalmology, University Paris Est Creteil, Centre Hospitalier Intercommunal de Creteil, Creteil, France; †Vitreous Retina Macula Consultants of New York, New York, New York; and ‡Department of Ophthalmology, New York University, New York, New York.
Retina. 2013 Oct;33(9):1881-7. doi: 10.1097/IAE.0b013e3182923448.
To analyze the multimodal imaging features of eyes with early Type 3 neovascularization showing primarily intraretinal proliferation without evidence of choroidal involvement.
The multimodal imaging data for a consecutive series of patients with new onset stage 1 Type 3 neovascularization were reviewed and the changes at the site of early lesion development were analyzed.
Nineteen eyes of 19 patients (12 women, mean age 79.9 ± 6.3 years) were included for analysis. Both fluorescein angiography and indocyanine green angiography showed a focal hyperfluorescence corresponding to the intraretinal vascular complex (early Type 3 neovascularization) and disclosed a single retinal arteriole feeding this lesion. There was no angiographic evidence of a retinal-choroidal anastomosis or underlying Type 1 or Type 2 neovascularization. In all study eyes, eye-tracked spectral-domain optical coherence tomography showed the intraretinal neovascular complex as a hyperreflective lesion located in the outer retina, which appeared adherent to the underlying retinal pigment epithelium. In all eyes, there seemed to be a focal discontinuity of the retinal pigment epithelium band through which the hyperreflective intraretinal lesions communicated with the underlying material of medium reflectivity within drusen or drusenoid pigment epithelium detachment. With spectral-domain optical coherence tomography, clear evidence of a communication with the choroid was not detected.
Multimodal imaging seems to support available clinicopathologic findings showing primarily intraretinal proliferation and anastomoses between retinal vessels and evolving Type 1 (subretinal pigment epithelium) neovascular tissue within underlying drusen or drusenoid pigment epithelium detachments without evidence of anastomoses with the choroidal circulation.
分析表现为单纯视网膜内增生而无脉络膜受累证据的早期 3 型新生血管的多模态成像特征。
回顾了一系列新发 1 期 3 型新生血管患者的多模态成像数据，并分析了早期病变发展部位的变化。
19 名患者（12 名女性，平均年龄 79.9±6.3 岁）的 19 只眼被纳入分析。荧光素血管造影和吲哚青绿血管造影均显示与视网膜内血管复合物（早期 3 型新生血管）相对应的局灶性强荧光，并显示出单一的视网膜小动脉为该病变供血。没有视网膜脉络膜吻合或潜在的 1 型或 2 型新生血管的血管造影证据。在所有研究眼中，眼追踪谱域光学相干断层扫描显示视网膜内新生血管复合物为位于外视网膜的高反射性病变，该病变似乎与下方的视网膜色素上皮附着。在所有眼中，视网膜色素上皮带似乎存在局灶性不连续性，通过该连续性，高反射性视网膜内病变与下方中等反射性物质（如 drusen 或 drusenoid 色素上皮脱离）相通。通过谱域光学相干断层扫描，并未明确检测到与脉络膜的连通证据。
多模态成像似乎支持现有的临床病理发现，即表现为单纯的视网膜内增生，以及在下方的 drusen 或 drusenoid 色素上皮脱离中，视网膜血管与正在形成的 1 型（色素上皮下）新生血管组织之间的吻合，而没有与脉络膜循环吻合的证据。
