老药阿司匹林的新配方，实现更好的给药效果。
New formulation of old aspirin for better delivery.
作者信息
Kalathil Akil A, Kumar Anil, Banik Bhabatosh, Ruiter Timothy A, Pathak Rakesh K, Dhar Shanta
机构信息
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA.
出版信息
Chem Commun (Camb). 2016 Jan 4;52(1):140-3. doi: 10.1039/c5cc07316b.
Abstract
For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.
摘要
为了更好地利用阿司匹林的环氧化酶依赖性抗炎特性和线粒体活性，人们开发了阿司匹林的新型疏水类似物，并成功将其封装在聚合物纳米颗粒（NPs）中。使用小鼠模型对这些纳米颗粒进行的体内抗炎作用表明，一种优化的阿司匹林类似物具有独特的特性，能够抑制促炎细胞因子的产生并促进抗炎细胞因子的富集。
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