Center for Human Genetics, KU Leuven, Leuven, Belgium, and at the Center for the Biology of Disease, VIB, Leuven, Belgium.
Nat Genet. 2015 Nov;47(11):1226-7. doi: 10.1038/ng.3428.
Adult T cell leukemia/lymphoma (ATL) is a neoplasm linked to human T-lymphotropic virus type-1 (HTLV-1) infection and is refractory to current combination chemotherapy. A large genomic and transcriptomic study of ATL now provides detailed insight into the molecular lesions implicated in the development of this T cell malignancy.
成人 T 细胞白血病/淋巴瘤（ATL）是一种与人类 T 淋巴细胞白血病病毒 1 型（HTLV-1）感染相关的肿瘤，对当前的联合化疗具有抗药性。目前对 ATL 的大规模基因组和转录组研究为深入了解这种 T 细胞恶性肿瘤发展过程中涉及的分子病变提供了详细的信息。
