Cortés R, Camps M, Gueye B, Probst A, Palacios J M
Preclinical Research, Sandoz Ltd., Basel, Switzerland.
Brain Res. 1989 Mar 27;483(1):30-8. doi: 10.1016/0006-8993(89)90031-0.
The distribution and density of dopamine D1 and D2 receptors were examined by autoradiography in postmortem brain tissue from patients with pathological diagnosis of Parkinson's disease, status lacunaris, clinical parkinsonism without neuropathological lesions and in age-matched controls. The D1 antagonist [3H]SCH 23390 and the D2 agonist [3H]CV 205-502 were used as ligands. No significant differences in the distribution or density of D1 or D2 receptors were found in Parkinson's disease in the areas examined, including the nucleus caudatus, putamen, globus pallidus and substantia nigra. In contrast, cases presenting lacunar lesions in the striatum showed marked decreases in D1 and D2 receptor densities in this region. Patients clinically diagnosed as parkinsonians but without Parkinson's disease lesions or striatal lacunar softenings showed reduced densities of D2 receptors in the nucleus caudatus and putamen, while in the substantia nigra the densities were comparable to controls. In the basal ganglia of these cases D1 receptors were slightly decreased.
通过放射自显影术，对病理诊断为帕金森病、腔隙状态、临床帕金森综合征但无神经病理损伤患者以及年龄匹配的对照组的死后脑组织中多巴胺D1和D2受体的分布及密度进行了检测。D1拮抗剂[3H]SCH 23390和D2激动剂[3H]CV 205 - 502用作配体。在所检测的区域，包括尾状核、壳核、苍白球和黑质，帕金森病患者的D1或D2受体分布或密度未发现显著差异。相比之下，纹状体出现腔隙性病变的病例在该区域的D1和D2受体密度显著降低。临床诊断为帕金森综合征但无帕金森病病变或纹状体腔隙性软化的患者，其尾状核和壳核中的D2受体密度降低，而黑质中的密度与对照组相当。在这些病例的基底神经节中，D1受体略有减少。
