Barazzoni R, Gortan Cappellari G, Semolic A, Ius M, Mamolo L, Dore F, Giacca M, Zanetti M, Vinci P, Guarnieri G
Internal Medicine, Dept of Medical, Surgical and Health Science, University of Trieste, Trieste, Italy.
Internal Medicine, Dept of Medical, Surgical and Health Science, University of Trieste, Trieste, Italy.
Clin Nutr. 2016 Oct;35(5):1168-73. doi: 10.1016/j.clnu.2015.10.002. Epub 2015 Oct 22.
BACKGROUND & AIMS: Ghrelin is a gastric hormone circulating in acylated (AG) and unacylated (UG) forms, and higher plasma total ghrelin (TG) and UG may be cross-sectionally associated with lower insulin resistance in metabolic syndrome patients. The potential value of ghrelin forms in predicting insulin resistance and its time-related changes in community-based population cohorts remains unknown.
We measured TG, AG and calculated UG (TG-AG) in 716 individuals from the North-East-Italy MoMa study (age: 55 ± 9 years, BMI: 29 ± 5 kg/m(2), M/F:349/367) to test the hypothesis that circulating TG and UG, but not AG are negatively associated with insulin resistance (HOMA). We further hypothesized that baseline TG and UG negatively predict 5-year HOMA changes in a 350-individual subgroup.
Baseline TG and UG were associated negatively with HOMA after adjusting for gender and body mass index (BMI). Baseline gender- and BMI-adjusted TG and UG were also negatively associated with HOMA at 5-year follow-up (n = 350), and changes in TG and UG were negatively associated with changes in HOMA (P < 0.05) after adjustment for anthropometric and metabolic confounders. No statistically significant correlations were observed between AG and baseline or 5-year HOMA.
In a North-East Italy community-based population cohort, plasma TG and UG but not AG are negatively associated with HOMA. TG and UG and their changes also independently predict 5-year HOMA changes. TG and UG are therefore novel potential modulators of insulin resistance and may contribute to predict its time-related changes in humans.
胃饥饿素是一种以酰化（AG）和去酰化（UG）形式循环的胃激素，在代谢综合征患者中，较高的血浆总胃饥饿素（TG）和UG水平可能与较低的胰岛素抵抗呈横断面相关。胃饥饿素各形式在预测胰岛素抵抗及其在社区人群队列中的时间相关变化方面的潜在价值尚不清楚。
我们对意大利东北部MoMa研究中的716名个体（年龄：55±9岁，体重指数：29±5kg/m²，男/女：349/367）测量了TG、AG并计算了UG（TG-AG），以检验循环TG和UG而非AG与胰岛素抵抗（HOMA）呈负相关的假设。我们进一步假设，在一个350人的亚组中，基线TG和UG可负向预测5年HOMA的变化。
在校正性别和体重指数（BMI）后，基线TG和UG与HOMA呈负相关。在5年随访时（n = 350），经性别和BMI校正的基线TG和UG也与HOMA呈负相关，在校正人体测量和代谢混杂因素后，TG和UG的变化与HOMA的变化呈负相关（P < 0.05）。未观察到AG与基线或5年HOMA之间有统计学显著相关性。
在意大利东北部以社区为基础的人群队列中，血浆TG和UG而非AG与HOMA呈负相关。TG和UG及其变化也可独立预测5年HOMA的变化。因此，TG和UG是胰岛素抵抗的新型潜在调节因子，可能有助于预测其在人类中的时间相关变化。
