Veiga Luisa, Brito Miguel, Silva Carina, Silva-Nunes José
Health and Technology Research Center (H&TRC), Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa, Lisbon, Portugal.
Centro de Estatística e Aplicações, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.
Biomark Insights. 2020 Jun 5;15:1177271920928923. doi: 10.1177/1177271920928923. eCollection 2020.
Unacylated ghrelin (UAG) is the major form of circulating ghrelin. Initially considered as a nonfunctional peptide, soon after, UAG has been associated to an insulin sensitizing action and to a negative action on energy balance. The aim of this study was to analyze the association between the serum levels of UAG and glucose metabolism parameters in obese women, independently from eventual influence of anthropometrics.
One hundred lean and 254 obese Caucasian women were studied. Each woman was characterized for anthropometrics, fasting glucose, insulin, HbA1c, and UAG. In addition, obese women were subjected to a classic oral glucose tolerance test (oGTT) to assess glucose and insulin at 120 minutes. Insulin resistance was assessed by the homeostasis model assessment (HOMA-IR). Obese women were classified in 3 glycemic status subgroups (normoglycemia, prediabetes, and diabetes) according to HbA1c and to fasting and oGTT glucose values.
In comparison with the lean group, significantly lower levels of UAG were observed in obese women. However, no significant difference was observed through obesity classes I to III. UAG levels were not significantly different among glycemic status subgroups and did not show any association with glucose, insulin, HOMA-IR, or HbA1c.
Although anthropometry can influence the level of the unacylated form of ghrelin, UAG plasma levels do not associate to glucose homeostasis parameters.
去酰基胃饥饿素（UAG）是循环中胃饥饿素的主要形式。最初被认为是一种无功能的肽，但此后不久，UAG就与胰岛素增敏作用以及对能量平衡的负面作用相关联。本研究的目的是分析肥胖女性血清UAG水平与糖代谢参数之间的关联，独立于人体测量学的最终影响。
对100名瘦的和254名肥胖的白人女性进行了研究。对每位女性进行了人体测量学、空腹血糖、胰岛素、糖化血红蛋白（HbA1c）和UAG的测定。此外，肥胖女性接受了经典的口服葡萄糖耐量试验（oGTT）以评估120分钟时的血糖和胰岛素水平。通过稳态模型评估（HOMA-IR）评估胰岛素抵抗。根据HbA1c以及空腹和oGTT血糖值，将肥胖女性分为3个血糖状态亚组（正常血糖、糖尿病前期和糖尿病）。
与瘦组相比，肥胖女性的UAG水平显著降低。然而，在I至III级肥胖中未观察到显著差异。血糖状态亚组之间的UAG水平无显著差异，并且与血糖、胰岛素、HOMA-IR或HbA1c均无关联。
尽管人体测量学可影响去酰基形式胃饥饿素的水平，但UAG血浆水平与葡萄糖稳态参数无关。
