Schwingel Fabiano L, Pizzichini Emilio, Kleveston Tulia, Morato Edelton F, Pinheiro José T, Steidle Leila J M, Dal-Pizzol Felipe, Rocha Cristiane C, Pizzichini Marcia M M
NUPAIVA, Federal University of Santa Catarina, Florianópolis, Brazil.
NUPAIVA, Federal University of Santa Catarina, Florianópolis, Brazil.
Ann Allergy Asthma Immunol. 2015 Dec;115(6):485-9. doi: 10.1016/j.anai.2015.10.003. Epub 2015 Oct 24.
Immune response has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD) and asthma. Pentraxin 3 (PTX3) is a multifunctional pattern recognition protein and an important component of the innate immune system that can be assessed in blood and induced sputum.
To determine whether PTX3 measured in induced sputum could discriminate patients with COPD from patients with asthma.
A cross-sectional study of 68 participants (27 with COPD, 25 with asthma, and 16 healthy controls) was performed. At study inclusion sputum was collected and total and differential cell numbers and PTX3 levels were determined.
Pentraxin 3 was detected in 89% of patients with COPD, 56% of patients with asthma, and 19% of controls (P = .001). It discriminated participants with COPD (24.6 ng/mL, 0-384 ng/mL) from controls (0 ng/mL, 0-36 ng/mL, P < .001) and from participants with asthma (1.2 ng/mL, 0-100 ng/mL, P = .01; area under the receiver operating curve 0.82 [0.71-0.94]). Regression analyses determined that sputum PTX3 and neutrophil counts were independently associated with COPD. In addition, PTX3 levels were independently associated with COPD severity.
Pentraxin 3 sputum levels are increased in patients with COPD and has good power to discriminate these patients from patients with asthma and healthy individuals.
免疫反应与慢性阻塞性肺疾病（COPD）和哮喘的发病机制有关。五聚体3（PTX3）是一种多功能模式识别蛋白，也是固有免疫系统的重要组成部分，可在血液和诱导痰中进行检测。
确定诱导痰中检测到的PTX3是否能够区分COPD患者和哮喘患者。
对68名参与者（27名COPD患者、25名哮喘患者和16名健康对照者）进行了一项横断面研究。在研究纳入时收集痰液，测定总细胞数、分类细胞数和PTX3水平。
89%的COPD患者、56%的哮喘患者和19%的对照者检测到五聚体3（P = 0.001）。它能够区分COPD参与者（24.6 ng/mL，0 - 384 ng/mL）与对照者（0 ng/mL，0 - 36 ng/mL，P < 0.001）以及哮喘参与者（1.2 ng/mL，0 - 100 ng/mL，P = 0.01；受试者工作特征曲线下面积为0.82 [0.71 - 0.94]）。回归分析确定，痰液PTX3和中性粒细胞计数与COPD独立相关。此外，PTX3水平与COPD严重程度独立相关。
COPD患者痰液中PTX3水平升高，并且在区分这些患者与哮喘患者和健康个体方面具有良好的能力。
