使用阿立哌唑和拉莫三嗪治疗的心境障碍患者焦虑、静坐不能及自杀观念增加
Increased Anxiety, Akathisia, and Suicidal Thoughts in Patients with Mood Disorder on Aripiprazole and Lamotrigine.
作者信息
Pondé Milena Pereira, Freire Antonio Carlos Cruz
机构信息
BAHIANA School of Medicine and Public Health, Avenida Dom João VI, No. 275, Brotas, 40290-000 Salvador, BA, Brazil.
出版信息
Case Rep Psychiatry. 2015;2015:419746. doi: 10.1155/2015/419746. Epub 2015 Oct 5.
Abstract
Introduction. Akathisia affects around 18% of patients with bipolar disorder treated with aripiprazole and may worsen when aripiprazole is combined with lamotrigine and antidepressants. Case. This paper reports on two clinical cases involving patients with a diagnosis of mood disorder who developed severe akathisia, anxiety, and suicidal ideation while using a combination of aripiprazole, antidepressants, and lamotrigine. Discussion. We recommend that patients with a mood disorder taking multiple drugs should begin aripiprazole therapy with low doses and be monitored for the development of akathisia, increased anxiety, or suicidal thoughts. The appearance of these limiting side effects requires discontinuation of the drug.
摘要
引言。静坐不能影响约18%接受阿立哌唑治疗的双相情感障碍患者，且当阿立哌唑与拉莫三嗪及抗抑郁药联用时可能会加重。病例。本文报告两例临床病例，患者被诊断为心境障碍，在联用阿立哌唑、抗抑郁药和拉莫三嗪时出现了严重的静坐不能、焦虑和自杀观念。讨论。我们建议，服用多种药物的心境障碍患者应从小剂量开始阿立哌唑治疗，并监测静坐不能、焦虑增加或自杀想法的出现。这些限制性副作用一旦出现，就需要停药。
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本文引用的文献
1
Pregabalin-induced akathisia.
Ann Pharmacother. 2013 Apr;47(4):592-3. doi: 10.1345/aph.1R699. Epub 2013 Mar 27.
2
Aripiprazole-associated acute dystonia, akathisia, and parkinsonism in a patient with bipolar I disorder.
J Clin Psychopharmacol. 2013 Apr;33(2):269-70. doi: 10.1097/JCP.0b013e3182856826.
3
Serotonin toxicity in aripiprazole augmentation.
J Neuropsychiatry Clin Neurosci. 2012 Winter;24(1):E36-7. doi: 10.1176/appi.neuropsych.11020051.
4
Aripiprazole in combination with lamotrigine for the long-term treatment of patients with bipolar I disorder (manic or mixed): a randomized, multicenter, double-blind study (CN138-392).
Bipolar Disord. 2012 Feb;14(1):41-53. doi: 10.1111/j.1399-5618.2011.00974.x.
5
Aripiprazole in bipolar depression: a pooled, post-hoc analysis by severity of core depressive symptoms.
Int J Psychiatry Clin Pract. 2012 Jun;16(2):121-31. doi: 10.3109/13651501.2011.632680. Epub 2012 Feb 1.
6
The effectiveness and safety of adjunctive aripiprazole in Taiwanese patients with antidepressant-refractory major depressive disorder: a prospective, open-label trial.
J Clin Psychopharmacol. 2012 Feb;32(1):56-60. doi: 10.1097/JCP.0b013e31823f6c7f.
7
Aripiprazole associated with acute dystonia, akathisia, and parkinsonism in a single patient.
J Clin Pharmacol. 2012 Sep;52(9):1448-9. doi: 10.1177/0091270011414573. Epub 2011 Sep 8.
8
Aripiprazole-associated bruxism, akathisia, and parkinsonism in a bipolar patient.
J Clin Psychopharmacol. 2011 Feb;31(1):134-5. doi: 10.1097/JCP.0b013e3182048cce.
9
Aripiprazole in acute mania and long-term treatment of bipolar disorder: a critical review by an Italian working group.
Clin Drug Investig. 2010;30(12):827-841. doi: 10.2165/11584270-000000000-00000.
10
Analysis of suicidality in pooled data from 2 double-blind, placebo-controlled aripiprazole adjunctive therapy trials in major depressive disorder.
J Clin Psychiatry. 2011 Apr;72(4):548-55. doi: 10.4088/JCP.09m05495gre. Epub 2010 Aug 24.
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