McKibben Rebeccah A, Zhao Di, Lutsey Pamela L, Schneider Andrea L C, Guallar Eliseo, Mosley Thomas H, Michos Erin D
Department of Medicine (R.A.M., E.D.M.), Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287; Department of Epidemiology (D.Z., A.L.C.S., E.G., E.D.M.), Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205; Division of Epidemiology and Community Health (P.L.L.), School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455; and Department of Medicine (T.H.M.), University of Mississippi Medical Center, Jackson, Mississippi 39216.
J Clin Endocrinol Metab. 2016 Jan;101(1):33-43. doi: 10.1210/jc.2015-1711. Epub 2015 Oct 28.
A single measurement of 25-hydroxyvitamin D (25 [OH] D) may not accurately reflect long-term vitamin D status. Little is known about change in 25(OH)D levels over time, particularly among blacks.
The objective of the study was to determine the longitudinal changes in 25(OH)D levels among Atherosclerosis Risk in Communities (ARIC) study participants.
This was a longitudinal study.
The study was conducted in the general community.
A total of 9890 white and 3222 black participants at visit 2 (1990-1992), 888 whites and 876 blacks at visit 3 (1993-1994), and 472 blacks at the brain visit (2004-2006) participated in the study.
The 25(OH)D levels were measured, and regression models were used to assess the associations between clinical factors and longitudinal changes in 25(OH)D.
Vitamin D deficiency (<50 nmol/L [<20 ng/mL]) was seen in 23% and 25% of whites at visits 2 and 3, and in 61%, 70%, and 47% of blacks at visits 2, 3, and the brain visit, respectively. The 25(OH)D levels were correlated between visits 2 and 3 (3 y interval) among whites (r = 0.73) and blacks (r = 0.66). Among blacks, the correlation between visit 2 and the brain visit (14 y interval) was 0.33. Overall, increases in 25(OH)D levels over time was associated with male gender, use of vitamin D supplements, greater physical activity, and higher high-density lipoprotein-cholesterol (P < .001). Decreases in 25(OH)D levels over time were associated with current smoking, higher body mass index, higher education, diabetes, and hypertension (all P < .05).
Among US blacks and whites, 25(OH)D levels remained relatively stable over time. Certain modifiable lifestyle factors were associated with change in 25(OH)D levels over time.
单次测量25-羟基维生素D（25[OH]D）可能无法准确反映长期维生素D状态。关于25(OH)D水平随时间的变化情况，人们了解甚少，尤其是在黑人中。
本研究的目的是确定社区动脉粥样硬化风险（ARIC）研究参与者中25(OH)D水平的纵向变化。
这是一项纵向研究。
研究在普通社区进行。
共有9890名白人参与者和3222名黑人参与者在第2次随访（1990 - 1992年）时参与研究，888名白人参与者和876名黑人参与者在第3次随访（1993 - 1994年）时参与研究，472名黑人参与者在脑部随访（2004 - 2006年）时参与研究。
测量25(OH)D水平，并使用回归模型评估临床因素与25(OH)D纵向变化之间的关联。
在第2次和第3次随访时，分别有23%和25%的白人存在维生素D缺乏（<50 nmol/L [<20 ng/mL]），在第2次、第3次和脑部随访时，分别有61%、70%和47%的黑人存在维生素D缺乏。白人在第2次和第3次随访（间隔3年）之间以及黑人在这两次随访之间的25(OH)D水平具有相关性（白人r = 0.73，黑人r = 0.66）。在黑人中，第2次随访与脑部随访（间隔14年）之间的相关性为0.33。总体而言，随着时间推移，25(OH)D水平升高与男性性别、使用维生素D补充剂、更多的体力活动以及更高的高密度脂蛋白胆固醇有关（P < .001）。随着时间推移，25(OH)D水平降低与当前吸烟、更高的体重指数、更高的教育程度、糖尿病和高血压有关（所有P < .05）。
在美国黑人和白人中，25(OH)D水平随时间相对保持稳定。某些可改变的生活方式因素与25(OH)D水平随时间的变化有关。
