Department of Health Sciences, Lehman College, City University of New York, Bronx, NY 10468, USA.
Ann Epidemiol. 2013 Jul;23(7):409-14. doi: 10.1016/j.annepidem.2013.05.011.
To investigate the relationship between body mass index (BMI) and optimal vitamin D status in U.S. adults.
Data on 12,927 adults 18 years and older participating in National Health and Nutrition Examination Surveys 2001-2006 were used. Serum levels of 25-hydroxy vitamin D 30 ng/mL or greater was used as a measure of vitamin D sufficiency. Log-binomial regression was used to estimate the strength of the association between BMI categories and the prevalence of vitamin D sufficiency before and after adjusting for selected characteristics.
After adjustment, overweight and obese individuals were 24% and 55%, respectively, less likely to have a 25-hydroxy vitamin D level of 30 ng/mL or greater compared with their normal-weight counterparts.
Our findings call attention to the importance of identifying individuals at risk for vitamin D insufficiency and its potential adverse health outcomes because the latter may increase health disparities in the U.S. population. If vitamin D insufficiency is implicated for chronic diseases such as cardiovascular diseases and diabetes, a vitamin D supplementation regimen would need to be readdressed, especially for segments of the U.S. population with greater BMIs.
探讨美国成年人的体重指数（BMI）与最佳维生素 D 状态之间的关系。
使用了参加 2001-2006 年国家健康和营养调查的 12927 名 18 岁及以上成年人的数据。血清 25-羟维生素 D 水平≥30ng/ml 被用作维生素 D 充足的衡量标准。采用对数二项式回归来估计 BMI 类别与维生素 D 充足率之间的关联强度，在调整了选定特征后进行了分析。
调整后，与体重正常者相比，超重和肥胖者的 25-羟维生素 D 水平≥30ng/ml 的可能性分别低 24%和 55%。
我们的研究结果表明，需要重视识别维生素 D 不足的高危人群及其潜在的不良健康后果，因为这可能会增加美国人群中的健康差异。如果维生素 D 不足与心血管疾病和糖尿病等慢性疾病有关，那么维生素 D 补充方案需要重新考虑，特别是对于 BMI 较高的美国人群的某些部分。
