Kistler J, Bullivant S
Department of Cell Biology, University of Auckland, New Zealand.
Crit Rev Biochem Mol Biol. 1989;24(2):151-81. doi: 10.3109/10409238909086397.
Lens transparency is associated with a unique design in tissue development and architecture. The fiber plasma membrane has domains which link with the cytoskeleton, thus maintaining cell shape. Other membrane regions form processes which interlock adjacent lens fibers, and intercellular junctions contain transmembrane pores which allow passage of metabolites between cells. Much interest has recently focused on the study of lens membrane structure and function, mainly because membrane dysfunction may be associated with cataract formation. This article reviews what is known about the structure of membrane domains, about the identification of domain-specific proteins, and describes current attempts to relate these results to function. Much of the presently available data is controversial, and an attempt will be made to reconcile them in revised models and testable hypotheses.
晶状体的透明性与组织发育和结构中的独特设计相关。纤维质膜具有与细胞骨架相连的结构域，从而维持细胞形状。其他膜区域形成与相邻晶状体纤维相互连锁的突起，并且细胞间连接含有跨膜孔，允许代谢物在细胞间通过。最近，人们对晶状体膜结构和功能的研究兴趣浓厚，主要是因为膜功能障碍可能与白内障的形成有关。本文综述了关于膜结构域的已知信息、结构域特异性蛋白质的鉴定，并描述了目前将这些结果与功能联系起来的尝试。目前可得的许多数据存在争议，将尝试在修订模型和可检验假设中对它们进行协调。
