通过非对映发散性芳基化去芳构化反应连接重氮酰胺A和氮嗪的酪氨酸和色氨酸单元。
Connecting Tyrosine and Tryptophan Units of Diazonamide A and Azonazine by a Diastereodivergent Arylative Dearomatization.
作者信息
Denizot Natacha, Guillot Régis, Kouklovsky Cyrille, Vincent Guillaume
机构信息
Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Equipe Méthodologie, Synthèse et Molécules Thérapeutiques, Univ Paris Sud, CNRS, Université Paris-Saclay, 91405, Orsay (France).
出版信息
Chemistry. 2015 Dec 21;21(52):18953-6. doi: 10.1002/chem.201503612. Epub 2015 Nov 11.
We report the Friedel-Crafts coupling of a tyrosine unit with tryptophan-derived pyrrolindolenium ions which are configurationally stable. The reaction allowed the stereoselective and divergent access to the required quaternary stereocenters found in diazonamide A and azonazine at the junction of the tyrosine and tryptophan units.
我们报道了酪氨酸单元与构型稳定的色氨酸衍生的吡咯啉鎓离子之间的傅克偶联反应。该反应使得能够立体选择性地、多样化地构建在重氮酰胺A和氮嗪中酪氨酸和色氨酸单元连接处所需的季碳立体中心。
Zotero 插件