Han J, Zhen L, Pan M, Yang X, Ou Y-M, Liao C, Li D-Z
Prenatal Diagnostic Centre, Guangzhou Women and Children's Medical Centre affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
Prenatal Diagnostic Centre, Guangzhou Women and Children's Medical Centre affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
Eur J Obstet Gynecol Reprod Biol. 2015 Dec;195:100-102. doi: 10.1016/j.ejogrb.2015.10.001. Epub 2015 Oct 17.
To determine the influence of free invasive prenatal testing on the uptake of non-invasive prenatal testing (NIPT).
Over a 2-year period at a Chinese tertiary prenatal diagnostic unit, women at risk of fetal trisomy were given the option of NIPT or invasive prenatal testing. Invasive prenatal testing was offered free of charge to women with a local Hukou (household registration); however, women without a local Hukou were charged for invasive prenatal testing. Both women with and without a local Hukou were charged for NIPT.
During the first year, 2647 women with a positive trisomy 21 screening test were referred (474 women with a local Hukou and 2173 women without a local Hukou). Only 1.6% of the women with a local Hukou underwent NIPT, while this proportion was 20.6% in the women without a local Hukou. During the second year, the price of NIPT was reduced. The total number of women referred was 3047 (502 women with a local Hukou and 2545 women without a local Hukou). The uptake of NIPT in women without a local Hukou doubled, but the uptake of NIPT remained stable in women with a local Hukou.
The financial impact on the uptake of NIPT should not be underestimated.
确定免费侵入性产前检测对无创产前检测（NIPT）接受率的影响。
在一家中国三级产前诊断单位的两年时间里，有胎儿三体风险的女性可以选择NIPT或侵入性产前检测。有当地户口（户籍）的女性可免费接受侵入性产前检测；然而，没有当地户口的女性进行侵入性产前检测是收费的。有和没有当地户口的女性进行NIPT均需收费。
在第一年，2647名21三体筛查试验呈阳性的女性被转诊（474名有当地户口的女性和2173名没有当地户口的女性）。只有1.6%有当地户口的女性接受了NIPT，而在没有当地户口的女性中这一比例为20.6%。在第二年，NIPT的价格降低了。被转诊的女性总数为3047名（502名有当地户口的女性和2545名没有当地户口的女性）。没有当地户口的女性对NIPT的接受率翻了一番，但有当地户口的女性对NIPT的接受率保持稳定。
经济因素对NIPT接受率的影响不应被低估。
