Lubetzky Ronit, Argov-Argaman Nurit, Mimouni Francis B, Armoni Domany Keren, Shiff Yaffa, Berkovitz Zipi, Reifen Ram, Mandel Dror
a Departments of Neonatology and Pediatrics , Tel Aviv Medical Center , Tel Aviv , Israel .
b Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel , and.
J Matern Fetal Neonatal Med. 2016 Sep;29(18):3041-4. doi: 10.3109/14767058.2015.1114082. Epub 2015 Nov 30.
To test the null hypothesis that mothers of asymmetric small for gestational age (SGA) infants produce milk with fatty acids composition similar to that of lactating mothers of appropriate-for-gestational-age (AGA) infants.
We obtained human milk (HM) from 2 groups of lactating volunteers that gave birth to asymmetric SGA (study group) or AGA infants (control group). Each mother was asked to contribute by manual expression at least one of 3 samples: first 72 hours after labor (colostrum), day 2-7 postpartum (transitional milk) and 14 days post partum (mature milk). After lipid extraction using Folch's cold-extraction procedure fatty acids were analyzed using gas chromatography.
A total of 108 samples were obtained in 60 women. In univariate analysis, there were no significant differences in any of the fatty acids concentrations examined between groups. This remained true when timing of the sample (colostrum, transitional or mature milk) or gestational age were introduced as confounders in analysis of variance (general linear model).
Fatty acid composition of human milk is not affected by whether or not the infant was fetal growth restricted. We suggest that mothers of SGA infants may be reassured about the fat quality of their milk.
检验零假设，即不对称小于胎龄（SGA）婴儿的母亲所产母乳的脂肪酸组成与适于胎龄（AGA）婴儿的哺乳期母亲的母乳脂肪酸组成相似。
我们从两组哺乳期志愿者中获取了母乳（HM），这两组志愿者分别分娩出不对称SGA婴儿（研究组）或AGA婴儿（对照组）。要求每位母亲通过手动挤奶提供至少3份样本中的1份：分娩后最初72小时（初乳）、产后第2 - 7天（过渡乳）和产后14天（成熟乳）。使用福尔克冷萃取法提取脂质后，采用气相色谱法分析脂肪酸。
60名女性共提供了108份样本。在单变量分析中，两组之间所检测的任何脂肪酸浓度均无显著差异。当在方差分析（一般线性模型）中将样本时间（初乳、过渡乳或成熟乳）或胎龄作为混杂因素纳入分析时，情况依然如此。
母乳的脂肪酸组成不受婴儿是否存在胎儿生长受限的影响。我们建议，SGA婴儿的母亲可以放心其母乳的脂肪质量。
