Gao Yongfei, Feng Jianfeng, Zhu Lin
Key Laboratory of Pollution Process and Environmental Criteria of Ministry of Education and Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China.
Key Laboratory of Pollution Process and Environmental Criteria of Ministry of Education and Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China.
Aquat Toxicol. 2015 Dec;169:37-45. doi: 10.1016/j.aquatox.2015.09.005. Epub 2015 Oct 22.
The biotic ligand model (BLM) and the toxicokinetic-toxicodynamic (TK-TD) model are essential in predicting the acute toxicity of metals in various species and exposure conditions; however, these models are usually separately utilized. In this study, a mechanistic TK-TD model was developed to predict the acute toxicity of 10(-6)M Cd and 10(-6)M Pb to zebrafish (Danio rerio) larvae. The novel approach links the BLM with relevant TK processes to simulate the bioaccumulation processes of Cd or Pb as a function of the maximum uptake rate of each metal, the affinity constants, and the concentrations of free metal ions and H(+) in test solutions. Results showed that the refined TK-TD model can accurately predict the accumulation and acute toxicity of Cd and Pb to zebrafish larvae at pH 5.5, 6.5, and 7.0.
生物配体模型（BLM）和毒代动力学-毒效动力学（TK-TD）模型对于预测各种物种在不同暴露条件下金属的急性毒性至关重要；然而，这些模型通常是单独使用的。在本研究中，开发了一种机制性的TK-TD模型来预测10(-6)M镉和10(-6)M铅对斑马鱼（Danio rerio）幼体的急性毒性。这种新方法将BLM与相关的TK过程联系起来，以模拟镉或铅的生物累积过程，该过程是每种金属的最大摄取率、亲和常数以及测试溶液中游离金属离子和H(+)浓度的函数。结果表明，改进后的TK-TD模型能够准确预测在pH值为5.5、6.5和7.0时镉和铅对斑马鱼幼体的累积和急性毒性。
