脂滴调节自噬体生物发生。
Lipid droplets regulate autophagosome biogenesis.
作者信息
Shpilka Tomer, Elazar Zvulun
机构信息
a Department of Biological Chemistry ; The Weizmann Institute of Science ; Rehovot , Israel.
b Current address: Cell Biology Program; Memorial Sloan Kettering Cancer Center ; New York , NY , USA.
出版信息
Autophagy. 2015 Nov 2;11(11):2130-2131. doi: 10.1080/15548627.2015.1093719.
Abstract
The source of the autophagic membrane and the regulation of autophagosome biogenesis are still elusive open issues in the field of autophagy. In our recent study of the role of lipid droplets (LDs) and their constituents in autophagy, we provided evidence that both the biogenesis of LDs and its lipolysis by specific lipases are important for autophagosome biogenesis. Our study sheds new light on the source of the autophagic membrane and suggests that a flow of membranes from the endoplasmic reticulum (ER) to LDs, and from LDs to the ER, is essential for autophagosome biogenesis.
摘要
自噬膜的来源以及自噬体生物发生的调控仍是自噬领域尚未解决的重要问题。在我们最近关于脂滴（LDs）及其成分在自噬中作用的研究中，我们提供了证据表明脂滴的生物发生及其通过特定脂肪酶的脂解作用对于自噬体生物发生都很重要。我们的研究为自噬膜的来源提供了新的线索，并表明从内质网（ER）到脂滴以及从脂滴到内质网的膜流对于自噬体生物发生至关重要。
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