自噬体生物发生与内质网：植物视角。
Autophagosome Biogenesis and the Endoplasmic Reticulum: A Plant Perspective.
机构信息
Center for Cell and Developmental Biology, State Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; These authors contributed equally to this work.
Center for Cell and Developmental Biology, State Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; Current address: Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1 14476, Potsdam-Golm, Germany; These authors contributed equally to this work.
出版信息
Trends Plant Sci. 2018 Aug;23(8):677-692. doi: 10.1016/j.tplants.2018.05.002. Epub 2018 Jun 18.
The autophagosome is a double-membrane compartment formed during autophagy that sequesters and delivers cargoes for their degradation or recycling into the vacuole. Analyses of the AuTophaGy-related (ATG) proteins have unveiled dynamic mechanisms for autophagosome biogenesis. Recent advances in plant autophagy research highlight a complex interplay between autophagosome biogenesis and the endoplasmic reticulum (ER): on the one hand ER serves as a membrane source for autophagosome initiation and a signaling platform for autophagy regulation; on the other hand ER turnover is connected to selective autophagy. We provide here an integrated view of ER-based autophagosome biogenesis in plants in comparison with the newest findings in yeast and mammals, with an emphasis on the hierarchy of the core ATG proteins, ATG9 trafficking, and ER-resident regulators in autophagy.
自噬体是自噬过程中形成的双层膜隔室，用于隔离和输送货物进行降解或回收进入液泡。对自噬相关（ATG）蛋白的分析揭示了自噬体生物发生的动态机制。植物自噬研究的最新进展强调了自噬体生物发生和内质网（ER）之间的复杂相互作用：一方面，ER 是自噬体起始的膜源，也是自噬调控的信号平台；另一方面，ER 的周转与选择性自噬有关。我们在这里提供了一个与酵母和哺乳动物的最新发现相比，基于 ER 的植物自噬体生物发生的综合视图，重点是核心 ATG 蛋白的层次结构、ATG9 运输和自噬中的 ER 驻留调节剂。
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