Sasson Inbal, Beharier Ofer, Sergienko Ruslan, Szaingurten-Solodkin Irit, Kessous Roy, Belfair Nadav J, Sheiner Eyal
a Department of Obstetrics and Gynecology , Faculty of Health Sciences, Soroka University Medical Center .
b Department of Physiology and Cell Biology , Faculty of Health Sciences .
J Matern Fetal Neonatal Med. 2016 Sep;29(18):2924-8. doi: 10.3109/14767058.2015.1114087. Epub 2015 Nov 30.
To investigate whether patients with a history of obesity during pregnancy have an increased risk for subsequent long-term ophthalmic complications, after controlling for diabetes and preeclampsia.
A population-based study compared the incidence of long-term maternal ophthalmic complications in a cohort of women with and without a history of obesity during pregnancy. Deliveries occurred between the years 1988 and 2013, with a mean follow-up duration of 12 years.
During the study period 106 220 deliveries met the inclusion criteria; 2.2% (n = 2353) occurred in patients with a diagnosis of obesity during at least one of their pregnancies. These patients had a significantly higher incidence of ophthalmic complications in total and specifically of diabetic retinopathy. Using a Kaplan-Meier survival curve, we found that patients with a history of obesity during pregnancy had a significantly higher cumulative incidence of ophthalmic complications. Using a Cox proportional hazards model, adjusted for confounders such as maternal age, preeclampsia and diabetes mellitus, we found obesity during pregnancy remained independently associated with ophthalmic complications (adjusted HR, 2.4; 95% CI, 1.4-4.2; p = 0.003).
Obesity during pregnancy is an independent risk factor for long-term ophthalmic complications, and specifically diabetic retinopathy.
在控制糖尿病和先兆子痫的情况下，调查孕期有肥胖史的患者随后发生长期眼科并发症的风险是否增加。
一项基于人群的研究比较了孕期有肥胖史和无肥胖史的女性队列中孕产妇长期眼科并发症的发生率。分娩发生在1988年至2013年之间，平均随访时间为12年。
在研究期间，106220例分娩符合纳入标准；2.2%（n = 2353）发生在至少一次怀孕期间被诊断为肥胖的患者中。这些患者的眼科并发症总发生率显著更高，尤其是糖尿病视网膜病变。使用Kaplan-Meier生存曲线，我们发现孕期有肥胖史的患者眼科并发症的累积发生率显著更高。使用Cox比例风险模型，对诸如产妇年龄、先兆子痫和糖尿病等混杂因素进行调整后，我们发现孕期肥胖仍然与眼科并发症独立相关（调整后的风险比，2.4；95%置信区间，1.4 - 4.2；p = 0.003）。
孕期肥胖是长期眼科并发症尤其是糖尿病视网膜病变的独立危险因素。
