粒细胞巨噬细胞集落刺激因子可恢复先天性角化不良中粒细胞 - 巨噬细胞骨髓造血祖细胞的体外生长。
Granulocytic macrophage colony stimulating factor restores in vitro growth of granulocyte-macrophage bone marrow hematopoietic progenitors in dyskeratosis congenita.
作者信息
Michalevicz R, Baron S, Nordan U, Rahmani R
机构信息
Institute of Hematology, Ichilov Hospital, Tel Aviv Medical Center, Israel.
出版信息
Isr J Med Sci. 1989 Apr;25(4):193-5.
PMID:2651350
Abstract
In vitro 14-day cultures of bone marrow from a patient with dyskeratosis congenita showed virtually no growth of colonies. The addition of recombinant granulocyte-macrophage colony stimulating factor (rGM-CSF) promoted a significant increase in the number of GM colonies (CFU-GM). Interleukin 3 also increased GM colony formation but to a lesser extent. GM-CSF may have a therapeutic implication for pancytopenia in dyskeratosis congenita.
摘要
先天性角化不良患者的骨髓进行体外14天培养，结果显示几乎没有集落生长。添加重组粒细胞-巨噬细胞集落刺激因子（rGM-CSF）可显著增加GM集落（CFU-GM）的数量。白细胞介素3也可增加GM集落形成，但程度较小。GM-CSF可能对先天性角化不良所致全血细胞减少症具有治疗意义。
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