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1
Human recombinant granulocyte-macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities.人重组粒细胞-巨噬细胞集落刺激因子和白细胞介素3具有重叠但不同的造血活性。
J Clin Invest. 1988 Oct;82(4):1282-7. doi: 10.1172/JCI113727.
2
Stimulation of human hematopoietic progenitor cell proliferation and differentiation by recombinant human interleukin 3. Comparison and interactions with recombinant human granulocyte-macrophage and granulocyte colony-stimulating factors.重组人白细胞介素3对人造血祖细胞增殖和分化的刺激作用。与重组人粒细胞-巨噬细胞集落刺激因子和粒细胞集落刺激因子的比较及相互作用。
Exp Hematol. 1989 Feb;17(2):191-7.
3
Human granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates immature marrow precursors but no CFU-GM, CFU-G, or CFU-M.人粒细胞巨噬细胞集落刺激因子（GM-CSF）刺激未成熟的骨髓前体细胞，但不刺激粒-巨噬细胞集落形成单位（CFU-GM）、粒细胞集落形成单位（CFU-G）或巨噬细胞集落形成单位（CFU-M）。
Exp Hematol. 1989 Mar;17(3):292-5.
4
Effect of stem cell factor (c-kit ligand), granulocyte-macrophage colony stimulating factor and interleukin 3 on hematopoietic progenitors in human long-term bone marrow cultures.干细胞因子（c-kit配体）、粒细胞-巨噬细胞集落刺激因子及白细胞介素3对人长期骨髓培养中造血祖细胞的影响
Stem Cells. 1993 Sep;11(5):435-44. doi: 10.1002/stem.5530110511.
5
Enrichment of CD34 (My10)-positive myeloid and erythroid progenitors from human marrow and their growth in cultures supplemented with recombinant human granulocyte-macrophage colony-stimulating factor.从人骨髓中富集CD34（My10）阳性髓系和红系祖细胞及其在补充重组人粒细胞-巨噬细胞集落刺激因子的培养物中的生长。
Exp Hematol. 1988 Oct;16(9):785-9.
6
Interleukin-11 stimulates the proliferation of human hematopoietic CD34+ and CD34+CD33-DR- cells and synergizes with stem cell factor, interleukin-3, and granulocyte-macrophage colony-stimulating factor.白细胞介素-11刺激人造血CD34+和CD34+CD33-DR-细胞的增殖，并与干细胞因子、白细胞介素-3和粒细胞-巨噬细胞集落刺激因子协同作用。
Exp Hematol. 1993 Dec;21(13):1668-72.
7
Mechanism of synergy between granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in colony formation from human marrow cells in vitro.粒细胞-巨噬细胞集落刺激因子与粒细胞集落刺激因子在体外人骨髓细胞集落形成中的协同作用机制。
Exp Hematol. 1989 Aug;17(7):816-21.
8
Recombinant murine granulocyte-macrophage (GM) colony-stimulating factor supports formation of GM and multipotential blast cell colonies in culture: comparison with the effects of interleukin-3.重组小鼠粒细胞-巨噬细胞（GM）集落刺激因子可支持培养物中GM集落和多能原始细胞集落的形成：与白细胞介素-3作用的比较。
J Cell Physiol. 1987 Jun;131(3):458-64. doi: 10.1002/jcp.1041310319.
9
Effect of recombinant human interleukin 3, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor on human BFU-e in serum-free cultures.重组人白细胞介素3、粒细胞-巨噬细胞集落刺激因子和粒细胞集落刺激因子对无血清培养中人类爆式红系集落形成单位的影响。
Int J Cell Cloning. 1989 Jan;7(1):39-49. doi: 10.1002/stem.5530070106.
10
Modulation of the activity of a human granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein (pIXY 321) by the macrocyclic lactone protein kinase C activator bryostatin 1.大环内酯类蛋白激酶C激活剂苔藓抑素1对人粒细胞-巨噬细胞集落刺激因子/白细胞介素-3融合蛋白（pIXY 321）活性的调节作用
Exp Hematol. 1993 Jul;21(7):893-900.

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Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells.嵌合抗原受体修饰 T 细胞对人急性髓系白血病和骨髓清除的临床前靶向作用。
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5
The role of CD40/CD40 ligand interactions in bone marrow granulopoiesis.CD40/CD40配体相互作用在骨髓粒细胞生成中的作用。
ScientificWorldJournal. 2011;11:2011-9. doi: 10.1100/2011/671453. Epub 2011 Oct 26.
6
Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice.粒细胞/巨噬细胞集落刺激因子对小鼠CD5阳性巨噬细胞发育和分化的影响及其源自CD5阳性B细胞谱系的可能性
Am J Pathol. 1998 Feb;152(2):445-56.
7
Effects of macrophage colony-stimulating factor on macrophages and their related cell populations in the osteopetrosis mouse defective in production of functional macrophage colony-stimulating factor protein.巨噬细胞集落刺激因子对骨硬化症小鼠中巨噬细胞及其相关细胞群体的影响，该小鼠在功能性巨噬细胞集落刺激因子蛋白的产生方面存在缺陷。
Am J Pathol. 1996 Aug;149(2):559-74.
8
Molecular regulation of the human IL-3 gene: inducible T cell-restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites.人类白细胞介素-3基因的分子调控：诱导性T细胞限制性表达需要完整的AP-1和Elf-1核蛋白结合位点。
J Exp Med. 1993 Nov 1;178(5):1681-92. doi: 10.1084/jem.178.5.1681.
9
The tolerability of continuous intravenous infusion of interleukin-3 after DHAP chemotherapy in patients with relapsed malignant lymphoma. A phase-I study.复发恶性淋巴瘤患者在DHAP化疗后持续静脉输注白细胞介素-3的耐受性。一项I期研究。
Ann Hematol. 1993 Oct;67(4):175-81. doi: 10.1007/BF01695864.
10
A 29,000 molecular weight fraction from fetal rat liver adhering cells that cooperates with erythropoietin in stimulating the growth of erythroid progenitors.来自胎鼠肝脏贴壁细胞的一种分子量为29,000的组分，它在刺激红系祖细胞生长方面与促红细胞生成素协同作用。
In Vitro Cell Dev Biol Anim. 1993 Oct;29A(10):782-8. doi: 10.1007/BF02634345.

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Isolation of human haematopoietic progenitor cells using monoclonal antibodies.利用单克隆抗体分离人造血祖细胞。
Nature. 1980 Sep 25;287(5780):332-3. doi: 10.1038/287332a0.
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Production of erythroid-potentiating activity by a human T-lymphoblast cell line.人T淋巴母细胞系产生促红细胞生成活性。
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Direct stimulation by purified GM-CSF of the proliferation of multipotential and erythroid precursor cells.纯化的粒细胞-巨噬细胞集落刺激因子对多能和红系祖细胞增殖的直接刺激作用。
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A cell line secreting stimulating factors for CFU-GEMM culture.一种分泌用于CFU-GEMM培养的刺激因子的细胞系。
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Human megakaryocytic progenitors (CFU-M) assayed in methylcellulose: physical characteristics and requirements for growth.在甲基纤维素中检测的人巨核细胞祖细胞（CFU-M）：物理特性和生长需求。
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Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins.人粒细胞-巨噬细胞集落刺激因子：互补DNA的分子克隆以及天然和重组蛋白的纯化。
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Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hematopoietin.人重组粒细胞-巨噬细胞集落刺激因子：一种多谱系造血生长因子。
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人重组粒细胞-巨噬细胞集落刺激因子和白细胞介素3具有重叠但不同的造血活性。

Human recombinant granulocyte-macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities.

作者信息

Emerson S G, Yang Y C, Clark S C, Long M W

机构信息

Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109.

出版信息

J Clin Invest. 1988 Oct;82(4):1282-7. doi: 10.1172/JCI113727.

DOI:10.1172/JCI113727
PMID:3049674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC442680/
Abstract

The hematopoietic stimulatory activities of human recombinant IL-3 and granulocyte-macrophage colony stimulating factor (GM-CSF) were directly compared using highly enriched human bone marrow progenitor target cells. IL-3 supported a larger number of erythroid and megakaryocytic progenitor cells than did GM-CSF, while GM-CSF supported more myeloid progenitors. IL-3 directly stimulated the division and migration of primitive erythroid burst forming units, while GM-CSF merely sustained their net survival in culture without promoting division and expansion. IL-3 promoted the formation of larger numbers of multipotential granulocyte-erythroid-macrophage-megakaryocyte colony forming unit--derived colonies than did GM-CSF. These data indicate that human IL-3 and GM-CSF have overlapping but distinct hematopoietic activities, and suggest a potential role for the clinical application of combined IL-3/GM-CSF therapy.

摘要

使用高度富集的人骨髓祖细胞靶细胞，直接比较了人重组白细胞介素-3（IL-3）和粒细胞-巨噬细胞集落刺激因子（GM-CSF）的造血刺激活性。与GM-CSF相比，IL-3支持更多的红系和巨核系祖细胞，而GM-CSF支持更多的髓系祖细胞。IL-3直接刺激原始红系爆式形成单位的分裂和迁移，而GM-CSF仅维持其在培养中的净存活，而不促进分裂和扩增。与GM-CSF相比，IL-3促进形成更多的多能粒细胞-红系-巨噬细胞-巨核细胞集落形成单位衍生集落。这些数据表明，人IL-3和GM-CSF具有重叠但不同的造血活性，并提示IL-3/GM-CSF联合疗法在临床应用中的潜在作用。