Eldar M
Laser Research Laboratory, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Isr J Med Sci. 1989 Apr;25(4):222-8.
Laser angioplasty enables the removal of atheromatous material from arterial plaques, and may reduce the rate of restenosis, which is the main problem with balloon angioplasty. Extensive experimental work seems to indicate that pulse-mode lasers (such as excimer) are more suitable than continuous-mode lasers, while the wavelength may be of less importance for plaque removal. However, optical fibers capable of transmitting the laser radiation are available for only certain laser wavelengths, and their absence may presently limit the use of some potentially effective lasers (such as CO2 and excimer). Catheter systems are crucial for clinical application; they provide efficient laser-fiber coupling, protect the distal tip and improve the efficiency and accuracy of laser emission. The coupling of balloon and laser angioplasty, and the "hot tip" thermal laser angioplasty have extended the potential use of laser angioplasty. Clinical application in the peripheral arteries, and experimental coronary human laser angioplasty studies, are described.
激光血管成形术能够从动脉斑块中去除粥样物质，并可能降低再狭窄率，而再狭窄是球囊血管成形术的主要问题。大量实验工作似乎表明，脉冲模式激光（如准分子激光）比连续模式激光更适用，而波长对于去除斑块可能不太重要。然而，能够传输激光辐射的光纤仅适用于某些激光波长，目前缺乏光纤可能会限制一些潜在有效激光（如二氧化碳激光和准分子激光）的使用。导管系统对于临床应用至关重要；它们提供高效的激光-光纤耦合，保护远端尖端并提高激光发射的效率和准确性。球囊血管成形术与激光血管成形术的结合，以及“热尖端”热激光血管成形术扩展了激光血管成形术的潜在用途。文中描述了其在外周动脉的临床应用以及实验性人体冠状动脉激光血管成形术研究。
