Lammer J, Pilger E, Kleinert R, Ascher P W
Rofo. 1987 Aug;147(2):119-23. doi: 10.1055/s-2008-1048605.
The first in-vivo trials were carried out on arteries of the extremities which have a straight course and short segmental occlusions. Initial experience indicates that obstructions up to 20 cm in length can be overcome by burning through plaques and thrombotic material by means of a neodymium-YAG-laser and then recanalised. By using a 2.2 mm spherical sapphire, one obtains a channel of 2.5 mm diameter through the obstruction. Subsequently dilatation with a balloon catheter is necessary. Laser angioplasty does not complicate the procedure significantly as far as the patient is concerned, since both the laser catheter and the balloon can be introduced through the same No. 7 F introducer into the femoral artery. Peripheral emboli could not be demonstrated angiographically, nor were they clinically manifest. On the basis of present experience, it seems that recanalisation of occlusions in arteries in the extremities, using a neodymium-YAG-laser focused by a synthetic sapphire, is a feasible alternative to conventional mechanical recanalisation.
首次体内试验是在四肢动脉上进行的，这些动脉走行笔直且节段性闭塞较短。初步经验表明，通过钕钇铝石榴石激光烧灼斑块和血栓物质，然后再通，可以克服长达20厘米的阻塞。使用2.2毫米球形蓝宝石，可在阻塞部位形成直径为2.5毫米的通道。随后需要用球囊导管进行扩张。就患者而言，激光血管成形术并不会使手术显著复杂化，因为激光导管和球囊都可以通过同一根7F导管鞘插入股动脉。血管造影未显示外周栓子，临床上也未出现栓子表现。根据目前的经验，使用合成蓝宝石聚焦的钕钇铝石榴石激光对四肢动脉阻塞进行再通，似乎是传统机械再通的一种可行替代方法。
