Didato M A, Gioeli R, Priolisi A
Institute of Social and Preventive Pediatrics, University of Palermo, Italy.
Helv Paediatr Acta. 1989 Feb;43(4):283-94.
This paper reports a randomized clinical trial to study the effect of an intravenous gamma-globulin preparation to prevent sepsis in pre-term newborn infants. 80 infants were enrolled: 37 of birthweight less than or equal to 1500 g and 43 of birthweight 1501-2000 g. In each group 20 infants received an intravenous preparation of gamma-globulin (0.5 g/kg/wk); the remaining 17 and 20, respectively, served as control cases. No significant differences in the occurrence of sepsis were observed between the group receiving prophylactively intravenous gamma-globulin and the control group. This is particularly evident in infants under intensive care (35% of the total population): in this group 2/3 of sepsis occurred in infants who received IgG. Among the infants with sepsis, the presence of an umbilical artery catheterization represented a significant risk-factor. The post-dose increment of serum IgG did not differ significantly in infants with and without sepsis; the post-dose serum disappearance rate in concentration appears identical in the two groups.
本文报告了一项随机临床试验，以研究静脉注射丙种球蛋白制剂对预防早产儿败血症的效果。共纳入80名婴儿：37名出生体重小于或等于1500克，43名出生体重为1501 - 2000克。每组中20名婴儿接受静脉注射丙种球蛋白制剂（0.5克/千克/周）；其余17名和20名分别作为对照病例。接受预防性静脉注射丙种球蛋白的组与对照组在败血症发生率上未观察到显著差异。这在重症监护的婴儿中尤为明显（占总人群的35%）：在该组中，2/3的败血症发生在接受免疫球蛋白G的婴儿中。在患有败血症的婴儿中，脐动脉插管是一个显著的危险因素。败血症患儿和非败血症患儿血清免疫球蛋白G的剂量后增量无显著差异；两组中剂量后血清浓度的消失率似乎相同。
