Başaranoğlu Serdar, Sıddık Evsen Mehmet, Ağaçayak Elif, Tunç Senem Yaman, Yılmaz Zülfikar, Yıldırım Yaşar, Deregözü Avşeqüi, Sak Muhammet Erdal, Yıldırım Zeynep Baysal, Kavak Gönül Ölmez, Gül Talip
a Department of Obstetrics and Gynecology , School of Medicine, Fatih University , Istanbul , Turkey .
b Department of Obstetrics and Gynecology , School of Medicine, Dicle University , Diyarbakir , Turkey .
J Matern Fetal Neonatal Med. 2016 Sep;29(18):2929-33. doi: 10.3109/14767058.2015.1108403. Epub 2015 Nov 23.
The purpose of the present study is twofold: (a) to investigate the etiology of disseminated intravascular coagulopathy (DIC) caused by obstetrical conditions and (b) to present parameters that can be used in predicting DIC-related mortality in obstetrical patients.
Obstetrical patients who had a delivery at or were referred (after delivery) to Obstetrics and Gynecology Clinic of Dicle University between July 2006 and December 2013 were retrospectively analyzed in this study. Those patients diagnosed with DIC were included in the study.
Fifty-six obstetrical patients carrying the diagnosis of DIC were included in this study. The overall mortality rate was 25% among these patients. More specifically, the mortality rate was 10.7% among patients with a DIC score ≤5 and 40.7% among those with a DIC score > 5. Multiple logistic regression analysis resulted in the finding that international normalized ratio (INR) and urea were among those factors affecting mortality in obstetrical DIC [OR: 8.44 (CI: 1.9-36.8), OR: 1.05 (CI: 1.0-1.1), respectively].
DIC is a syndrome that might be caused by obstetrical conditions. It is associated with high mortality and morbidity rates. In obstetrical DIC, urea is the most important factor affecting mortality. In addition, we are of the opinion that DIC score might guide mortality predictions as a determinant of prognosis.
本研究有两个目的：（a）调查产科相关弥散性血管内凝血（DIC）的病因；（b）提出可用于预测产科患者DIC相关死亡率的参数。
本研究回顾性分析了2006年7月至2013年12月期间在狄克莱大学妇产科诊所分娩或产后转诊的产科患者。纳入那些被诊断为DIC的患者。
本研究纳入了56例诊断为DIC的产科患者。这些患者的总死亡率为25%。更具体地说，DIC评分≤5的患者死亡率为10.7%，DIC评分>5的患者死亡率为40.7%。多因素逻辑回归分析发现，国际标准化比值（INR）和尿素是影响产科DIC死亡率的因素[比值比分别为：8.44（95%置信区间：1.9 - 36.8），1.05（95%置信区间：1.0 - 1.1）]。
DIC是一种可能由产科情况引起的综合征。它与高死亡率和发病率相关。在产科DIC中，尿素是影响死亡率的最重要因素。此外，我们认为DIC评分作为预后的决定因素可能指导死亡率预测。
