Pyeon S Y, Park J Y, Ulak R, Seol H J, Lee J M
Eur J Gynaecol Oncol. 2015;36(5):602-4.
The metastasis of cervical cancer to the brain is usually associated with systemic involvement such as lungs, liver and bones, and isolated brain metastasis is very rare because the primary mechanism of spread is by hematogenous dissemination of tumor cells. Although a few cases of isolated brain metastasis from cervical cancer have been reported, isolated brain metastasis from neuroendocrine cell carcinoma, which is characterized with aggressive and early metastatic features, has never been reported. A 44-year-old woman with cervical cancer composed of large neuroendocrine cell carcinoma was diagnosed with isolated brain metastasis at eight months after the definitive treatment with surgery followed by adjuvant chemotherapy. Careful evaluation would be needed during follow-up for the patients with cervical cancer with aggressive histologic type.
宫颈癌脑转移通常与肺、肝和骨等全身受累有关，孤立性脑转移非常罕见，因为其主要传播机制是肿瘤细胞的血行播散。尽管已有少数宫颈癌孤立性脑转移的病例报道，但以侵袭性和早期转移为特征的神经内分泌细胞癌的孤立性脑转移从未见报道。一名44岁患有大神经内分泌细胞癌的宫颈癌女性患者，在接受手术及辅助化疗的确定性治疗8个月后被诊断为孤立性脑转移。对于组织学类型侵袭性强的宫颈癌患者，随访期间需要进行仔细评估。
