Grodberg J, Dunn J J
Department of Microbiology, State University of New York, Stony Brook 11794.
J Bacteriol. 1989 May;171(5):2903-5. doi: 10.1128/jb.171.5.2903-2905.1989.
The predicted amino acid sequence of OmpT, an Escherichia coli outer membrane protease, was found to be highly homologous to that predicted for the pgtE gene product of Salmonella typhimurium. In this paper, it is shown that pgtE codes for a protein functionally homologous to OmpT as judged by its ability to proteolyze T7 RNA polymerase and to localize in the outer membrane of E. coli.
已发现大肠杆菌外膜蛋白酶OmpT的预测氨基酸序列与鼠伤寒沙门氏菌pgtE基因产物的预测序列高度同源。本文表明,根据pgtE对T7 RNA聚合酶进行蛋白水解以及定位于大肠杆菌外膜的能力判断,pgtE编码的蛋白质在功能上与OmpT同源。