Vieillard Vincent, Debré Patrice
Biol Aujourdhui. 2015;209(2):161-6. doi: 10.1051/jbio/2015019. Epub 2015 Oct 29.
In spite of numerous attempts, only one vaccine candidate showed a potentiality to prevent HIV infection. Such capacity, unfortunately partial, was due to the activity of specific antibodies, indicating the importance of humoral responses. However, the lack of a specific target did not allow to identify an epitope able to stimulate such a response. In addition, in view of a vaccine with preventive and therapeutic activities, it seems of interest to both be able to neutralize the virus and prevent its pathogenesis. We have identified a gp41 peptide inducing antibodies with such dual properties, therefore representing a future vaccine candidate to test functional capacities to fight HIV infection.
尽管进行了无数次尝试，但只有一种候选疫苗显示出预防HIV感染的潜力。这种能力，不幸的是部分能力，是由于特异性抗体的活性，这表明体液反应的重要性。然而，由于缺乏特定靶点，无法确定能够刺激这种反应的表位。此外，鉴于一种具有预防和治疗活性的疫苗，能够中和病毒并预防其发病机制似乎都很有意义。我们已经鉴定出一种gp41肽，它能诱导具有这种双重特性的抗体，因此代表了一种未来的候选疫苗，可用于测试对抗HIV感染的功能能力。
