Tocchini Cristina, Ciosk Rafal
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
Semin Cell Dev Biol. 2015 Dec;47-48:52-9. doi: 10.1016/j.semcdb.2015.10.017. Epub 2015 Oct 26.
TRIM-NHL proteins are key regulators of developmental transitions, for example promoting differentiation, while inhibiting cell growth and proliferation, in stem and progenitor cells. Abnormalities in these proteins have been also associated with human diseases, particularly affecting muscular and neuronal functions, making them potential targets for therapeutic intervention. The purpose of this review is to provide a systematic and comprehensive summary on the most studied TRIM-NHL proteins, highlighting examples where connections were established between structural features, molecular functions and biological outcomes.
TRIM-NHL蛋白是发育转变的关键调节因子，例如在干细胞和祖细胞中促进分化，同时抑制细胞生长和增殖。这些蛋白的异常也与人类疾病有关，尤其影响肌肉和神经功能，使其成为治疗干预的潜在靶点。本综述的目的是对研究最多的TRIM-NHL蛋白进行系统而全面的总结，突出在结构特征、分子功能和生物学结果之间建立联系的实例。
