内体整合素信号促进存活。
Endosomal integrin signals for survival.
机构信息
Cancer Research UK, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
出版信息
Nat Cell Biol. 2015 Nov;17(11):1373-5. doi: 10.1038/ncb3261.
DOI:10.1038/ncb3261
PMID:26515017
Abstract
The mechanisms underlying integrin-dependent signalling are a topic of continued study. Endocytosed integrins are now shown to drive assembly of signalling complexes on the cytoplasmic face of endocytic membranes to promote cancer cell survival and increase metastatic capacity following cell detachment.
摘要
整合素依赖性信号转导的机制是一个持续研究的课题。现在已经表明，内吞的整合素在细胞内体膜的细胞质侧驱动信号复合物的组装，以促进癌细胞存活，并在细胞脱离后增加转移能力。
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