内体：整合素介导的 FAK 信号转导的新兴平台。

Endosomes: Emerging Platforms for Integrin-Mediated FAK Signalling.

机构信息

Turku Centre for Biotechnology, University of Turku, FIN-20520 Turku, Finland.

Turku Centre for Biotechnology, University of Turku, FIN-20520 Turku, Finland; Department of Biochemistry and Food Chemistry, University of Turku, FIN-20520 Turku, Finland.

出版信息

Trends Cell Biol. 2016 Jun;26(6):391-398. doi: 10.1016/j.tcb.2016.02.001. Epub 2016 Mar 2.

DOI:10.1016/j.tcb.2016.02.001

PMID:26944773

Abstract

Integrins are vital cell adhesion receptors with the ability to transmit extracellular matrix (ECM) cues to intracellular signalling pathways. ECM-integrin signalling regulates various cellular functions such as cell survival and movement. Integrin signalling has been considered to occur exclusively from adhesion sites at the plasma membrane (PM). However, recent data demonstrates integrin signalling also from endosomes. Integrin-mediated focal adhesion kinase (FAK) signalling is strongly dependent on integrin endocytosis, and endosomal FAK signalling facilitates cancer metastasis by supporting anchorage-independent growth and anoikis resistance. Here we discuss the possible mechanisms and functions of endosomal FAK signalling compared with its previously known roles in other cellular locations and discuss the potential of endosomal FAK as novel target for future cancer therapies.

摘要

整合素是至关重要的细胞黏附受体，能够将细胞外基质 (ECM) 信号传递到细胞内信号通路。ECM-整合素信号调节各种细胞功能，如细胞存活和运动。整合素信号被认为仅发生在质膜 (PM) 的黏附部位。然而，最近的数据表明，整合素信号也发生在内体中。整合素介导的粘着斑激酶 (FAK) 信号强烈依赖于整合素内吞作用，内体 FAK 信号通过支持非锚定依赖性生长和抗 anoikis 来促进癌症转移。在这里，我们讨论了内体 FAK 信号的可能机制和功能与其在其他细胞位置的先前已知作用，并讨论了内体 FAK 作为未来癌症治疗新靶点的潜力。