Reprint of localized dose delivering by ion beam irradiation for experimental trial of establishing brain necrosis model.

作者信息

Takata Takushi, Kondo Natsuko, Sakurai Yoshinori, Tanaka Hiroki, Hasegawa Takashi, Kume Kyo, Suzuki Minoru

机构信息

Research Reactor Institute, Kyoto University, 2 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan; The Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga-shi, Fukui 914-0192, Japan.

Research Reactor Institute, Kyoto University, 2 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.

出版信息

Appl Radiat Isot. 2015 Dec;106:104-6. doi: 10.1016/j.apradiso.2015.10.008. Epub 2015 Oct 27.

DOI:10.1016/j.apradiso.2015.10.008

PMID:26515136

Abstract

Localized dose delivery techniques to establish a brain radiation necrosis model are described. An irradiation field was designed by using accelerated protons or helium ions with a spread-out Bragg peak. Measurement of the designed field confirmed that a high dose can be confined to a local volume of an animal brain. The irradiation techniques described here are very useful for establishing a necrosis model without existence of extraneous complications.

摘要