[Reaction of the brain to local irradiation with protons].

In experiments on dogs neurological syndromes and pathomorphological changes in the brain irradiated with a focussed beam of protons with an energy of 1,000 MEV in a static regime and with rotation in doses of 8,000; 30,000, and 32,000 rad were studied. The peculariaty of the method of morphological examination consisted in preparing transverse sections of the whole brain. With the higher doses penetrating cylinidrical or focal oval (depending on the irradiation conditions) necroses with distinct borders and a slight perifocal reaction were observed. Outside the focussing zone the tissue remained intact. The results obtained are intended for substrantiating stereotaxic operations on the brain.