Goutziomitrou Evangelia, Venetis Christos A, Kolibianakis Efstratios M, Bosdou Julia K, Parlapani Aggeliki, Grimbizis Gregoris, Tarlatzis Basil C
Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Greece.
Women's and Children's Health, St George Hospital, University of New South Wales, NSW, Australia.
Reprod Biomed Online. 2015 Dec;31(6):752-9. doi: 10.1016/j.rbmo.2015.08.013. Epub 2015 Sep 4.
Clinical outcomes of IVF cycles using propofol or thiopental sodium as anaesthetic agents for oocyte retrieval were compared. The primary outcome measure was fertilization rate per patient. One hundred and eighty patients undergoing ovarian stimulation with gonadotrophins and gonadotrophin-releasing hormone antagonists for IVF were randomized to receive either propofol (n = 90) or thiopental sodium (n = 90). No significant differences in baseline characteristics were present between the two groups. Overall fertilization rates were similar between propofol and thiopental sodium groups, respectively: median (IQR): 54.8 (29.2) versus 54.6 (29.7); fertilization rates for intracytoplasmic sperm injection only: median (IQR): 70 (50) versus 75 (50), respectively. For secondary outcome measures, time under anaesthesia was significantly increased in the thiopental sodium group: median (IQR): 12(5) versus 10 (4.5) min, P = 0.019 compared with the propofol group. Number of cumulus oocyte complexes retrieved [median (IQR): 7.1 (6.3) versus 6.5 (5.6)] did not differ significantly between the two groups. A non-significant difference in live birth rates per randomized patient of +4.4% (95% CI: -5.7 to +14.6) in favour of propofol was observed. Use of propofol compared with thiopental sodium for general anaesthesia during oocyte retrieval results in similar fertilization rates and IVF outcomes.
比较了使用丙泊酚或硫喷妥钠作为麻醉剂进行卵母细胞采集的体外受精周期的临床结局。主要结局指标是每位患者的受精率。180例接受促性腺激素和促性腺激素释放激素拮抗剂卵巢刺激以进行体外受精的患者被随机分为两组，分别接受丙泊酚（n = 90）或硫喷妥钠（n = 90）。两组之间的基线特征无显著差异。丙泊酚组和硫喷妥钠组的总体受精率相似，分别为：中位数（四分位间距）：54.8（29.2）对54.6（29.7）；仅卵胞浆内单精子注射的受精率分别为：中位数（四分位间距）：70（50）对75（50）。对于次要结局指标，硫喷妥钠组的麻醉时间显著延长：中位数（四分位间距）：12（5）分钟对10（4.5）分钟，与丙泊酚组相比，P = 0.019。两组间回收的卵丘卵母细胞复合体数量[中位数（四分位间距）：7.1（6.3）对6.5（5.6）]无显著差异。观察到随机分组患者中有利于丙泊酚的活产率有+4.4%的非显著差异（95%CI：-5.7至+14.6）。在卵母细胞采集期间使用丙泊酚与硫喷妥钠进行全身麻醉，受精率和体外受精结局相似。
