IVF Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar-Saba, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sci Rep. 2023 May 17;13(1):8021. doi: 10.1038/s41598-023-35224-2.
General anesthesia is frequently administered during oocyte retrieval. Its effects on the outcomes of IVF cycles are uncertain. This study investigated whether administration of general anesthesia (specifically propofol) during oocyte retrieval affects IVF outcomes. A total of 245 women undergoing IVF cycles were included in this retrospective cohort study. IVF outcomes of 129 women who underwent oocyte retrieval under propofol anesthesia and 116 without anesthesia were compared. Data were adjusted for age, BMI, estradiol on triggering day and total gonadotropin dose. The primary outcomes were fertilization, pregnancy and live birth rates. A secondary outcome was the efficiency of follicle retrieval associated with the use of anesthesia. Fertilization rate was lower in retrievals under anesthesia compared to without (53.4% ± 34.8 vs. 63.7% ± 33.6, respectively; p = 0.02). There was no significant difference in the ratio of expected to retrieved oocytes between retrievals with and without anesthesia (0.8 ± 0.4 vs. 0.8 ± 0.8, respectively, p = 0.96). The differences in pregnancy and live birth rates between the groups were not statistically significant. General anesthesia administered during oocyte retrieval may have adverse effects on the fertilization potential of oocytes. This impact on the developmental potential of oocytes may lead to negative IVF outcomes and should be investigated further.
全麻常用于取卵过程中。其对 IVF 周期结果的影响尚不确定。本研究旨在探讨取卵过程中给予全麻（具体为丙泊酚）是否会影响 IVF 结局。这项回顾性队列研究纳入了 245 例行 IVF 周期的妇女。比较了 129 例接受丙泊酚麻醉取卵和 116 例未接受麻醉取卵的妇女的 IVF 结局。数据经过年龄、BMI、触发日雌二醇和总促性腺激素剂量的调整。主要结局为受精率、妊娠率和活产率。次要结局为与使用麻醉相关的卵泡获取效率。与未接受麻醉相比，接受麻醉的取卵受精率较低（分别为 53.4%±34.8%和 63.7%±33.6%；p=0.02）。接受麻醉与未接受麻醉的取卵中预期获卵数与实际获卵数之比无显著差异（分别为 0.8±0.4 和 0.8±0.8，p=0.96）。两组间妊娠率和活产率无显著差异。取卵过程中给予全麻可能对卵子的受精潜能产生不良影响。这种对卵子发育潜能的影响可能导致 IVF 结局不佳，需要进一步研究。
