Pierro Maria, Ciralli Fabrizio, Colnaghi Mariarosa, Vanzati Mara, Mercadante Domenica, Consonni Dario, Mosca Fabio
a NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università Degli Studi Di Milano , Milan , Italy and.
b Epidemiology Unit, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico , Milan , Italy.
J Matern Fetal Neonatal Med. 2016;29(16):2675-80. doi: 10.3109/14767058.2015.1100161. Epub 2015 Oct 30.
The aim of the study was to retrospectively investigate the association between initial oxygen concentration in delivery room and short-term outcomes in preterm infants.
Data from infants needing neonatal resuscitation, born at our department between January 2008 and December 2011, were analyzed. Patients were divided into three groups based on gestational age: between 32 and 36 weeks, between 31 and 28 weeks, and below 28 weeks.
The administration of each additional unit of oxygen up to 50% showed an association with a 5% increased need for mechanical ventilation (MV) in the neonatal intensive care unit in infants between 32 and 36 weeks [adjusted odds ratio 1.1, 95% confidence interval (CI) 1.04-1.1] and infants between 28 and 31 weeks (adjusted odds ratio 1.12, 95% CI 1.08-1.44). On the contrary, in infants below 28 weeks, increasing initial concentration of supplementary oxygen did not show any association with MV.
Initial oxygen concentration seems to be associated with increased MV in the NICU. Our observations further stress the need for randomized controlled studies in order to obtain definitive recommendations for the optimal initial oxygen concentration during neonatal resuscitation of preterm infants.
本研究旨在回顾性调查产房初始氧浓度与早产儿短期预后之间的关联。
对2008年1月至2011年12月在我科出生的需要新生儿复苏的婴儿的数据进行分析。根据胎龄将患者分为三组：32至36周、31至28周和28周以下。
在32至36周的婴儿（调整后的优势比为1.1，95%置信区间[CI]为1.04 - 1.1）和28至31周的婴儿（调整后的优势比为1.12，95%CI为1.08 - 1.44）中，在新生儿重症监护病房，每增加一个单位的氧气直至50%的使用与机械通气（MV）需求增加5%相关。相反，在28周以下的婴儿中，补充氧气的初始浓度增加与MV无任何关联。
初始氧浓度似乎与新生儿重症监护病房中MV的增加有关。我们的观察结果进一步强调了进行随机对照研究的必要性，以便为早产儿新生儿复苏期间的最佳初始氧浓度获得明确的建议。
