From the *Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; †Department of Anesthesia, Ghent University, Gent, Belgium; ‡Demed, Temse, Belgium; §GlenPharma, Knutsford, Cheshire, United Kingdom; and ‖Department of Anesthesiology, Intensive Care, Rescue and Pain Medicine, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Anesth Analg. 2016 Jan;122(1):56-69. doi: 10.1213/ANE.0000000000001008.
Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted ("target") drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.
靶控输注（TCI）是一种静脉输注药物的技术，旨在在特定的身体腔室或感兴趣的组织中达到用户定义的预测（“靶”）药物浓度。在这篇综述中，我们描述了 TCI 的药代动力学原理、TCI 系统的发展以及原型开发中涉及的技术和监管问题。我们还描述了当前临床可用系统的推出。
