Cai Qiliang, Wang Xinpeng, Li Xiaodong, Gong Rui, Guo Xuemei, Tang Yang, Yang Kuo, Niu Yuanjie, Zhao Yan
Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Department of Radiotherapy, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Oncotarget. 2015 Dec 8;6(39):42312-21. doi: 10.18632/oncotarget.5994.
Numerous studies have investigated association between the germline HOXB13 p.Gly84Glu mutation and cancer risk. However, the results were inconsistent. Herein, we performed this meta-analysis to get a precise conclusion of the associations. A comprehensive literature search was conducted through Medline (mainly Pubmed), Embase, Cochrane Library databases. Crude odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated by STATA 12.1 software to evaluate the association of HOXB13 p.Gly84Glu mutation and cancer susceptibility. Then, 25 studies including 51,390 cases and 93,867 controls were included, and there was significant association between HOXB13 p.Gly84Glu mutation and overall cancer risk (OR = 2.872, 95% CI = 2.121-3.888, P < 0.001), particularly in prostate cancer (OR = 3.248, 95% CI = 2.313-4.560, P < 0.001), while no association was found in breast (OR = 1.424, 95% CI = 0.776-2.613, P = 0.253) and colorectal cancers (OR = 2.070, 95% CI = 0.485-8.841, P = 0.326). When we stratified analysis by ethnicity, significant association was found in Caucasians (OR = 2.673, 95%CI = 1.920-3.720, P < 0.001). Further well-designed with large samples and other various cancers should be performed to validate our results.
众多研究调查了种系HOXB13 p.Gly84Glu突变与癌症风险之间的关联。然而，结果并不一致。在此，我们进行了这项荟萃分析以得出这些关联的精确结论。通过Medline（主要是Pubmed）、Embase、Cochrane图书馆数据库进行了全面的文献检索。使用STATA 12.1软件计算粗比值比（OR）及其95%置信区间（CI），以评估HOXB13 p.Gly84Glu突变与癌症易感性之间的关联。然后，纳入了25项研究，包括51390例病例和93867例对照，HOXB13 p.Gly84Glu突变与总体癌症风险之间存在显著关联（OR = 2.872，95%CI = 2.121 - 3.888，P < 0.001），特别是在前列腺癌中（OR = 3.248，95%CI = 2.313 - 4.560，P < 0.001），而在乳腺癌（OR = 1.424，95%CI = 0.776 - 2.613，P = 0.253）和结直肠癌中未发现关联（OR = 2.070，95%CI = 0.485 - 8.841，P = 0.326）。当我们按种族进行分层分析时，在白种人中发现了显著关联（OR = 2.673，95%CI = 1.920 - 3.720，P < 0.001）。应进一步开展设计良好的大样本研究以及针对其他各种癌症的研究以验证我们的结果。
