Rajan A M, Rajkumar S V
Aureus University School of Medicine, Oranjestad, Aruba.
Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Blood Cancer J. 2015 Oct 30;5(10):e365. doi: 10.1038/bcj.2015.92.
The interpretation of cytogenetic abnormalities in multiple myeloma (MM) is often a challenging task. MM is characterized by several cytogenetic abnormalities that occur at various time points in the disease course. The interpretation of cytogenetic results in MM is complicated by the number and complexity of the abnormalities, the methods used to detect them and the disease stage at which they are detected. Specific cytogenetic abnormalities affect clinical presentation, progression of smoldering multiple myeloma (SMM) to MM, prognosis of MM and management strategies. The goal of this paper is to provide a review of how MM is classified into specific subtypes based on primary cytogenetic abnormalities and to provide a concise overview of how to interpret cytogenetic abnormalities based on the disease stage to aid clinical practice and patient management.
多发性骨髓瘤（MM）细胞遗传学异常的解读往往是一项具有挑战性的任务。MM的特征是在疾病进程的不同时间点出现多种细胞遗传学异常。MM细胞遗传学结果的解读因异常的数量和复杂性、检测它们所使用的方法以及检测到这些异常时的疾病阶段而变得复杂。特定的细胞遗传学异常会影响临床表现、冒烟型多发性骨髓瘤（SMM）向MM的进展、MM的预后以及管理策略。本文的目的是综述如何根据原发性细胞遗传学异常将MM分类为特定亚型，并简要概述如何根据疾病阶段解读细胞遗传学异常，以辅助临床实践和患者管理。
