Beedle Amy E M, Williams Aisling, Relat-Goberna Josep, Garcia-Manyes Sergi
Department of Physics and Randall Division of Cell and Molecular Biophysics, King's College London, Strand, London WC2R 2LS, UK.
Department of Physics and Randall Division of Cell and Molecular Biophysics, King's College London, Strand, London WC2R 2LS, UK.
Curr Opin Chem Biol. 2015 Dec;29:87-93. doi: 10.1016/j.cbpa.2015.09.019. Epub 2015 Oct 30.
The cell membrane is a highly complex designed material with remarkable physicochemical properties; comprised mainly of lipid moieties, it is capable of self-assembling, changing morphology, housing a range of distinct proteins, and withstanding electrical, chemical and mechanical perturbations. All of these fundamental cellular functions occurring within a 5nm thick film is an astonishing feat of engineering, made possible due to the interplay of a variety of intermolecular forces. Elucidating how the interactions within the chemically distinct partners influence the nanomechanical properties of the membrane is essential to gain a comprehensive understanding of a wide-variety of both force-triggered and force-sensing mechanisms that dictate essential cellular processes.
细胞膜是一种设计高度复杂、具有卓越物理化学性质的材料；它主要由脂质部分组成，能够自我组装、改变形态、容纳一系列不同的蛋白质，并能承受电、化学和机械扰动。所有这些基本细胞功能都发生在一个5纳米厚的薄膜内，这是一项惊人的工程壮举，由于多种分子间力的相互作用才得以实现。阐明化学性质不同的组分之间的相互作用如何影响膜的纳米力学性质，对于全面理解决定基本细胞过程的各种力触发和力传感机制至关重要。
